Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17

Summary for 4YDI

Related4YDJ 4YDK 4YDL
DescriptorEnvelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY Z258-VRC27.01, LIGHT CHAIN OF ANTIBODY Z258-VRC27.01, ... (7 entities in total)
Functional Keywordsantibody, hiv-1, immune system
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains3
Total molecular weight91247.74
Zhou, T.,Srivatsan, S.,Kwong, P.D. (deposition date: 2015-02-22, release date: 2015-06-03, Last modification date: 2015-06-17)
Primary citation
Zhou, T.,Lynch, R.M.,Chen, L.,Acharya, P.,Wu, X.,Doria-Rose, N.A.,Joyce, M.G.,Lingwood, D.,Soto, C.,Bailer, R.T.,Ernandes, M.J.,Kong, R.,Longo, N.S.,Louder, M.K.,McKee, K.,O'Dell, S.,Schmidt, S.D.,Tran, L.,Yang, Z.,Druz, A.,Luongo, T.S.,Moquin, S.,Srivatsan, S.,Yang, Y.,Zhang, B.,Zheng, A.,Pancera, M.,Kirys, T.,Georgiev, I.S.,Gindin, T.,Peng, H.P.,Yang, A.S.,Mullikin, J.C.,Gray, M.D.,Stamatatos, L.,Burton, D.R.,Koff, W.C.,Cohen, M.S.,Haynes, B.F.,Casazza, J.P.,Connors, M.,Corti, D.,Lanzavecchia, A.,Sattentau, Q.J.,Weiss, R.A.,West, A.P.,Bjorkman, P.J.,Scheid, J.F.,Nussenzweig, M.C.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161:1280-1292, 2015
PubMed: 26004070 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2015.05.007
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27770.7%1.5%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 4ydi
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