4YDI

Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G	Envelope glycoprotein gp160	polymer	359	39980.1	1	UniProt (O55774) Pfam (PF00516) In PDB	Human immunodeficiency virus 1
2	H	HEAVY CHAIN OF ANTIBODY Z258-VRC27.01	polymer	227	24897.0	1		Homo sapiens (Human)
3	L	LIGHT CHAIN OF ANTIBODY Z258-VRC27.01	polymer	210	23048.6	1		Homo sapiens (Human)
4	G, L	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)
5	G, H	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6	H	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
7		water	water		18.0	19	Chemie (HOH)

Sequence modifications

G: 44 - 123 (UniProt: O55774)
G: 199 - 317 (UniProt: O55774)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G: 324 - 492 (UniProt: O55774)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87925.7
Non-Polymers*	Number of molecules	18
	Total formula weight	3322.0
All*	Total formula weight	91247.7

*Water molecules are not included.