Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies

Summary for 6XDG

EMDB information22137
DescriptorSpike glycoprotein, REGN10933 antibody Fab fragment light chain, REGN10933 antibody Fab fragment heavy chain, ... (8 entities in total)
Functional Keywordssars-cov-2, therapeutic antibody, antiviral, viral protein-immune system complex, viral protein/immune system
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains5
Total molecular weight123571.61
Franklin, M.C.,Saotome, K.,Romero Hernandez, A.,Zhou, Y. (deposition date: 2020-06-10, release date: 2020-06-24, Last modification date: 2020-07-08)
Primary citation
Hansen, J.,Baum, A.,Pascal, K.E.,Russo, V.,Giordano, S.,Wloga, E.,Fulton, B.O.,Yan, Y.,Koon, K.,Patel, K.,Chung, K.M.,Hermann, A.,Ullman, E.,Cruz, J.,Rafique, A.,Huang, T.,Fairhurst, J.,Libertiny, C.,Malbec, M.,Lee, W.Y.,Welsh, R.,Farr, G.,Pennington, S.,Deshpande, D.,Cheng, J.,Watty, A.,Bouffard, P.,Babb, R.,Levenkova, N.,Chen, C.,Zhang, B.,Romero Hernandez, A.,Saotome, K.,Zhou, Y.,Franklin, M.,Sivapalasingam, S.,Lye, D.C.,Weston, S.,Logue, J.,Haupt, R.,Frieman, M.,Chen, G.,Olson, W.,Murphy, A.J.,Stahl, N.,Yancopoulos, G.D.,Kyratsous, C.A.
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Science, 2020
PubMed: 32540901 (PDB entries with the same primary citation)
DOI: 10.1126/science.abd0827
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers19 0.4% 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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