6XDG

Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Spike protein S1	polymer	251	28437.9	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein,Spike glycoprotein
2	B (D)	REGN10933 antibody Fab fragment light chain	polymer	214	23347.8	1		Homo sapiens (Human)
3	C (B)	REGN10933 antibody Fab fragment heavy chain	polymer	226	24142.1	1		Homo sapiens (Human)
4	D (C)	REGN10987 antibody Fab fragment heavy chain	polymer	225	24036.9	1		Homo sapiens (Human)
5	E (A)	REGN10987 antibody Fab fragment light chain	polymer	216	22804.2	1		Homo sapiens (Human)
6	F (F)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)

Sequence modifications

E: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 542	-	expression tag
Gln 543	-	expression tag
Lys 544	-	expression tag
Leu 545	-	expression tag
Ile 546	-	expression tag
Ser 547	-	expression tag
Glu 548	-	expression tag
Glu 549	-	expression tag
Asp 550	-	expression tag
Leu 551	-	expression tag
Gly 552	-	expression tag
Gly 553	-	expression tag
Glu 554	-	expression tag
Gln 555	-	expression tag
Lys 556	-	expression tag
Leu 557	-	expression tag
Ile 558	-	expression tag
Ser 559	-	expression tag
Glu 560	-	expression tag
Glu 561	-	expression tag
Asp 562	-	expression tag
Leu 563	-	expression tag
His 564	-	expression tag
His 565	-	expression tag
His 566	-	expression tag
His 567	-	expression tag
His 568	-	expression tag
His 569	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	122768.9
Branched	Number of molecules	1
	Total formula weight	748.7
All*	Total formula weight	123517.6

*Water molecules are not included.