8FIT
 
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8FIN
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2N0X
 | | Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry | | 分子名称: | Serum albumin | | 著者 | Perez-Castells, J, Canales, A, Jimenez-Barbero, J, Gimenez-Gallego, G. | | 登録日 | 2015-03-18 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and characterization of an endogenous CXCR4 antagonist.
Cell Rep, 11, 2015
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8FRE
 | | Designed loop protein RBL4 | | 分子名称: | 1,2-ETHANEDIOL, RBL4 | | 著者 | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | | 登録日 | 2023-01-06 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | De novo design of buttressed loops for sculpting protein functions.
Nat.Chem.Biol., 2024
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8FRF
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8EOZ
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6H9B
 | | 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation | | 分子名称: | 9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Varela, P.F, Gigant, B. | | 登録日 | 2018-08-03 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
J. Med. Chem., 62, 2019
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7SR6
 | | Human Endogenous Retrovirus (HERV-K) reverse transcriptase ternary complex with dsDNA template Primer and dNTP | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... | | 著者 | Baldwin, E.T, Nichols, C. | | 登録日 | 2021-11-08 | | 公開日 | 2022-07-20 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Proc.Natl.Acad.Sci.USA, 119, 2022
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2ESW
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2FR7
 | | Crystal Structure of Cytochrome P450 CYP199A2 | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, putative cytochrome P450 | | 著者 | Rao, Z, Wong, L.L, Xu, F, Bell, S.G. | | 登録日 | 2006-01-19 | | 公開日 | 2007-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris
J.Mol.Biol., 383, 2008
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8T5F
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | 分子名称: | Parathyroid hormone | | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | | 登録日 | 2023-06-13 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
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8T5E
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | 分子名称: | Bcl-2-like protein 11, Bim_fulldiff | | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | | 登録日 | 2023-06-13 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
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3RIN
 | | p38 kinase crystal structure in complex with small molecule inhibitor | | 分子名称: | Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-indol]-6'-yl)benzamide | | 著者 | Segarra, V, Eastwood, P, Roca, R, Fisher, M, Lamers, M. | | 登録日 | 2011-04-14 | | 公開日 | 2012-02-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Indolin-2-one p38(alpha) inhibitors I: design, profiling and crystallographic binding mode.
Bioorg.Med.Chem.Lett., 21, 2011
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3CTZ
 | | Structure of human cytosolic X-prolyl aminopeptidase | | 分子名称: | CALCIUM ION, HEXAETHYLENE GLYCOL, MANGANESE (II) ION, ... | | 著者 | Li, X, Lou, Z, Rao, Z. | | 登録日 | 2008-04-15 | | 公開日 | 2008-05-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
J.Biol.Chem., 283, 2008
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3S3I
 | | p38 kinase crystal structure in complex with small molecule inhibitor | | 分子名称: | 3-(3-tert-butyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-4-methylbenzamide, Mitogen-activated protein kinase 14 | | 著者 | Segarra, V, Aiguade, J, Roca, R, Fisher, M, Lamers, M. | | 登録日 | 2011-05-18 | | 公開日 | 2012-04-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Novel triazolopyridylbenzamides as potent and selective p38 alpha inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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8BZP
 | | JNK3 (Mitogen-activated protein kinase 10) in Complex with Compound 23 bearing a C(sp3)F2Br moiety | | 分子名称: | 1,2-ETHANEDIOL, 2-bromanyl-2,2-bis(fluoranyl)-~{N}-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)ethanamide, BETA-MERCAPTOETHANOL, ... | | 著者 | Stahlecker, J, Vaas, S, Stehle, T, Boeckler, F.M. | | 登録日 | 2022-12-15 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery.
J.Med.Chem., 66, 2023
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1FHJ
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1GHD
 | | Crystal structure of the glutaryl-7-aminocephalosporanic acid acylase by mad phasing | | 分子名称: | GLUTARYL-7-AMINOCEPHALOSPORANIC ACID ACYLASE | | 著者 | Ding, Y, Jiang, W, Mao, X, He, H, Zhang, S, Tang, H, Bartlam, M, Ye, S, Jiang, F, Liu, Y, Zhao, G, Rao, Z. | | 登録日 | 2000-12-07 | | 公開日 | 2003-07-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130.
J.Biol.Chem., 277, 2002
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1YQ3
 | | Avian respiratory complex ii with oxaloacetate and ubiquinone | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer, ... | | 著者 | Huang, L, Cobessi, D, Tung, E.Y, Berry, E.A. | | 登録日 | 2005-02-01 | | 公開日 | 2005-12-20 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme
J.Biol.Chem., 281, 2006
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1YQ4
 | | Avian respiratory complex ii with 3-nitropropionate and ubiquinone | | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 3-NITROPROPANOIC ACID, Coenzyme Q10, ... | | 著者 | Huang, L, Sun, G, Cobessi, D, Wang, A, Shen, J.T, Tung, E.Y, Anderson, V.E, Berry, E.A. | | 登録日 | 2005-02-01 | | 公開日 | 2005-12-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | 3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme
J.Biol.Chem., 281, 2006
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1ZRV
 | | solution structure of spinigerin in H20/TFE 50% | | 分子名称: | spinigerin | | 著者 | Landon, C, Meudal, H, Boulanger, N, Bulet, P, Vovelle, F. | | 登録日 | 2005-05-23 | | 公開日 | 2005-10-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation.
Biopolymers, 81, 2006
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1ZRX
 | | solution structure of stomoxyn in H20/TFE 50% | | 分子名称: | stomoxyn | | 著者 | Landon, C, Meudal, H, Boulanger, N, Bulet, P, Vovelle, F. | | 登録日 | 2005-05-23 | | 公開日 | 2005-10-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation.
Biopolymers, 81, 2006
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1ZRW
 | | solution structure of spinigerin in H20/TFE 10% | | 分子名称: | spinigerin | | 著者 | Landon, C, Meudal, H, Boulanger, N, Bulet, P, Vovelle, F. | | 登録日 | 2005-05-23 | | 公開日 | 2005-10-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation.
Biopolymers, 81, 2006
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3UBV
 | | Oxygen-bound hell's gate globin I by classical hanging drop | | 分子名称: | Hemoglobin-like flavoprotein, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Scudieri, D, Belmonte, L, Saito, J.A, Alam, M, Nicolini, C, Pechkova, E. | | 登録日 | 2011-10-25 | | 公開日 | 2012-03-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Oxygen-bound Hell's gate globin I by classical versus LB nanotemplate method.
J.Cell.Biochem., 8, 2012
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2IC4
 | | Solution structure of the His402 allotype of the Factor H SCR6-SCR7-SCR8 fragment | | 分子名称: | Complement factor H | | 著者 | Fernando, A.N, Furtado, P.B, Gilbert, H.E, Clark, S.J, Day, A.J, Sim, R.B, Perkins, S.J. | | 登録日 | 2006-09-12 | | 公開日 | 2007-04-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | SOLUTION SCATTERING | | 主引用文献 | Associative and Structural Properties of the Region of Complement Factor H Encompassing the Tyr402His Disease-related Polymorphism and its Interactions with Heparin.
J.Mol.Biol., 368, 2007
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