2N0X

Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry

Summary for 2N0X

Entry DOI	10.2210/pdb2n0x/pdb
NMR Information	BMRB: 25539
Descriptor	Serum albumin (1 entity in total)
Functional Keywords	antagonist, inhibitor peptide, peptide binding protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02768
Total number of polymer chains	1
Total formula weight	1833.20
Authors	Perez-Castells, J.,Canales, A.,Jimenez-Barbero, J.,Gimenez-Gallego, G. (deposition date: 2015-03-18, release date: 2015-04-29, Last modification date: 2023-06-14)
Primary citation	Zirafi, O.,Kim, K.A.,Standker, L.,Mohr, K.B.,Sauter, D.,Heigele, A.,Kluge, S.F.,Wiercinska, E.,Chudziak, D.,Richter, R.,Moepps, B.,Gierschik, P.,Vas, V.,Geiger, H.,Lamla, M.,Weil, T.,Burster, T.,Zgraja, A.,Daubeuf, F.,Frossard, N.,Hachet-Haas, M.,Heunisch, F.,Reichetzeder, C.,Galzi, J.L.,Perez-Castells, J.,Canales-Mayordomo, A.,Jimenez-Barbero, J.,Gimenez-Gallego, G.,Schneider, M.,Shorter, J.,Telenti, A.,Hocher, B.,Forssmann, W.G.,Bonig, H.,Kirchhoff, F.,Munch, J. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep, 11:737-747, 2015 Cited by PubMed: 25921529 DOI: 10.1016/j.celrep.2015.03.061 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation