2G5X
| Crystal structure of lychnin a type 1 Ribosome Inactivating Protein (RIP) | 分子名称: | Ribosome-inactivating protein | 著者 | Fermani, S, Falini, G, Tosi, G, Ripamonti, A, Polito, L, Bolognesi, A, Stirpe, F. | 登録日 | 2006-02-23 | 公開日 | 2007-03-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of lychnin a type 1 Ribosome Inactivating Protein (RIP) To be Published
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4FCQ
| Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization | 分子名称: | 4-(2,4-dimethylphenyl)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Heat shock protein HSP 90-alpha | 著者 | Davies, N.G, Browne, H, Davis, B, Foloppe, N, Geoffrey, S, Gibbons, B, Hart, T, Drysdale, M.J, Mansell, H, Massey, A, Matassova, N, Moore, J.D, Murray, J, Pratt, R, Ray, S, Roughley, S.D, Jensen, M.R, Schoepfer, J, Scriven, K, Simmonite, H, Stokes, S, Surgenor, A, Webb, P, Wright, L, Brough, P. | 登録日 | 2012-05-25 | 公開日 | 2012-10-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorg.Med.Chem., 20, 2012
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3UI4
| 0.8 A resolution crystal structure of human Parvulin 14 | 分子名称: | CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, SULFATE ION | 著者 | Mueller, J.W, Link, N.M, Matena, A, Hoppstock, L, Rueppel, A, Bayer, P, Blankenfeldt, W. | 登録日 | 2011-11-04 | 公開日 | 2011-12-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (0.8 Å) | 主引用文献 | Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases. J.Am.Chem.Soc., 133, 2011
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7Z3T
| Crystal structure of apo human Cathepsin L | 分子名称: | 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ... | 著者 | Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A. | 登録日 | 2022-03-02 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections. Commun Biol, 6, 2023
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7Z58
| Crystal structure of human Cathepsin L in complex with covalently bound Calpeptin | 分子名称: | 1,2-ETHANEDIOL, Calpeptin, Cathepsin L, ... | 著者 | Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A. | 登録日 | 2022-03-08 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections. Commun Biol, 6, 2023
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4FF7
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3BLJ
| Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment | 分子名称: | CHLORIDE ION, GLYCEROL, Poly(ADP-ribose) polymerase 15, ... | 著者 | Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Welin, M, Weigelt, J, Structural Genomics Consortium (SGC) | 登録日 | 2007-12-11 | 公開日 | 2007-12-25 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein. J.Biol.Chem., 290, 2015
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4V9R
| Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. | 登録日 | 2013-12-05 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep, 6, 2014
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4W9C
| pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 2) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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4W9R
| Crystal structure of uncharacterised protein Coch_1243 from Capnocytophaga ochracea DSM 7271 | 分子名称: | ACETATE ION, GLYCEROL, Uncharacterized protein | 著者 | Chang, C, Wu, R, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Crystal structure of uncharacterised protein Coch_1243 from Capnocytophaga ochracea DSM 7271 To Be Published
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4WBL
| Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation F235A | 分子名称: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, CHLORIDE ION, GLYCEROL | 著者 | Myllykoski, M, Raasakka, A, Kursula, P. | 登録日 | 2014-09-03 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase. Sci Rep, 5, 2015
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4UV3
| Structure of the curli transport lipoprotein CsgG in its membrane- bound conformation | 分子名称: | CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG | 著者 | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | 登録日 | 2014-08-04 | 公開日 | 2014-09-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | 主引用文献 | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg. Nature, 516, 2014
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4V3Q
| Designed armadillo repeat protein with 4 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | 分子名称: | CALCIUM ION, GLYCEROL, YIII_M4_AII | 著者 | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | 登録日 | 2014-10-20 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects. Acta Crystallogr D Struct Biol, 72, 2016
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3BX7
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6L4V
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4V0O
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4V5C
| Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA. | 分子名称: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Voorhees, R.M, Weixlbaumer, A, Loakes, D, Kelley, A.C, Ramakrishnan, V. | 登録日 | 2009-03-24 | 公開日 | 2014-07-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Insights Into Substrate Stabilization from Snapshots of the Peptidyl Transferase Center of the Intact 70S Ribosome Nat.Struct.Mol.Biol., 16, 2009
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4W1T
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6KOY
| Crystal structure of two domain M1 Zinc metallopeptidase E323A mutant bound to L-tryptophan amino acid | 分子名称: | TRYPTOPHAN, ZINC ION, Zinc metalloprotease | 著者 | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | 登録日 | 2019-08-13 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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4V84
| Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome. | 分子名称: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Zhu, J, Korostelev, A, Costantino, D, Noller, H.F, Kieft, J.S. | 登録日 | 2010-12-13 | 公開日 | 2014-07-09 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 108, 2011
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3C73
| Structure of CEHC variant ResA | 分子名称: | SULFATE ION, Thiol-disulfide oxidoreductase resA | 著者 | Crow, A. | 登録日 | 2008-02-06 | 公開日 | 2008-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Effects of substitutions in the CXXC active-site motif of the extracytoplasmic thioredoxin ResA. Biochem.J., 414, 2008
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3BK7
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4W8K
| Crystal structure of a putative Cas1 enzyme from Vibrio phage ICP1 | 分子名称: | Cas1 protein, POTASSIUM ION | 著者 | Stogios, P.J, Wawrzak, Z, Onopriyeno, O, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-08-25 | 公開日 | 2014-09-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | To be published To Be Published
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4W9D
| pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methyloxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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4UQK
| Electron density map of GluA2em in complex with quisqualate and LY451646 | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2 | 著者 | Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. | 登録日 | 2014-06-24 | 公開日 | 2014-08-13 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (16.4 Å) | 主引用文献 | Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
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