4HND
 
 | | Crystal structure of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha | | 著者 | Zhou, Q, Zhai, Y, Zhang, K, Chen, C, Sun, F. | | 登録日 | 2012-10-19 | | 公開日 | 2014-04-09 | | 最終更新日 | 2016-12-28 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
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4HNE
 | | Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha | | 著者 | Zhou, Q, Zhai, Y, Zhang, K, Chen, C, Sun, F. | | 登録日 | 2012-10-19 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
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6AZY
 | | Crystal structure of Hsp104 R328M/R757M mutant from Calcarisporiella thermophila | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Heat shock protein Hsp104 | | 著者 | Michalska, K, Bigelow, L, Hatzos-Skintges, C, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2017-09-13 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure, 27, 2019
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8YLC
 | | The crystal structure of PDE4D with Amentoflavone | | 分子名称: | 3',5'-cyclic-AMP phosphodiesterase 4D, 8-[5-[5,7-bis(oxidanyl)-4-oxidanylidene-chromen-2-yl]-2-oxidanyl-phenyl]-2-(4-hydroxyphenyl)-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ... | | 著者 | Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2024-03-06 | | 公開日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (2.30003715 Å) | | 主引用文献 | Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects
Chin.Chem.Lett., 2024
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3J1P
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6NDT
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6NDX
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6NDV
 | | FlgE D2 domain K336A mutant | | 分子名称: | Flagellar hook protein FlgE | | 著者 | Lynch, M.J, Crane, B.R. | | 登録日 | 2018-12-14 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.502 Å) | | 主引用文献 | Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook.
Nat.Chem.Biol., 15, 2019
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6NDW
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5XHQ
 | | Apolipoprotein N-acyl Transferase | | 分子名称: | Apolipoprotein N-acyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Yingzhi, X, Yong, X, Guangyuan, L, Fei, S. | | 登録日 | 2017-04-23 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.587 Å) | | 主引用文献 | Crystal structure of E. coli apolipoprotein N-acyl transferase
Nat Commun, 8, 2017
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5XV7
 | | SRPK1 in complex with Alectinib | | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | | 著者 | Zeng, C, Ngo, J.C.K. | | 登録日 | 2017-06-26 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
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1X92
 | | CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PHOSPHOHEPTOSE ISOMERASE IN COMPLEX WITH REACTION PRODUCT D-GLYCERO-D-MANNOPYRANOSE-7-PHOSPHATE | | 分子名称: | 7-O-phosphono-D-glycero-alpha-D-manno-heptopyranose, PHOSPHOHEPTOSE ISOMERASE | | 著者 | Walker, J.R, Evdokimova, E, Kudritska, M, Joachimiak, A, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2004-08-19 | | 公開日 | 2004-10-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
J.Biol.Chem., 283, 2008
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3L1V
 | | Crystal structure of GmhB from E. coli in complex with calcium and phosphate. | | 分子名称: | CALCIUM ION, D,D-heptose 1,7-bisphosphate phosphatase, PHOSPHATE ION, ... | | 著者 | Sugiman-Marangos, S.N, Junop, M.S. | | 登録日 | 2009-12-14 | | 公開日 | 2010-01-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | | 主引用文献 | Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.
Biochemistry, 49, 2010
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6AVO
 | | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes | | 分子名称: | N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | | 著者 | Li, H, Santos, R, Bai, L. | | 登録日 | 2017-09-04 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nat Commun, 8, 2017
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3L1U
 | | Crystal structure of Calcium-bound GmhB from E. coli. | | 分子名称: | CALCIUM ION, D,D-heptose 1,7-bisphosphate phosphatase, ZINC ION | | 著者 | Sugiman-Marangos, S.N, Junop, M.S. | | 登録日 | 2009-12-14 | | 公開日 | 2010-01-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.
Biochemistry, 49, 2010
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6PMO
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8GQP
 | | Complex of D-protein binder D-19437 and L-target L-Pep-1 | | 分子名称: | D-binder, L-pep1 | | 著者 | Liang, M.F, Li, S.C, Wang, T.Y, Liu, L, Lu, P.L. | | 登録日 | 2022-08-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Accurate de novo design of heterochiral protein-protein interactions
Cell Res., 2024
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6UIB
 | | Crystal structure of IL23 bound to peptide 23-652 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | | 著者 | Durbin, J.D, Wang, J, Afshar, S. | | 登録日 | 2019-09-30 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.
Plos One, 15, 2020
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6POM
 | | Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly | | 分子名称: | T-box GlyQS leader (155-MER), tRNAGly (75-MER) | | 著者 | Li, S, Su, Z, Zhang, J, Chiu, W. | | 登録日 | 2019-07-04 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions.
Nat.Struct.Mol.Biol., 26, 2019
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7YPN
 | | Crystal structure of transaminase CC1012 mutant M9 complexed with PLP | | 分子名称: | 1,2-ETHANEDIOL, Aspartate aminotransferase family protein, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Yang, L, Wang, H, Wei, D. | | 登録日 | 2022-08-03 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7YPM
 | | Crystal structure of transaminase CC1012 complexed with PLP and L-alanine | | 分子名称: | 1,2-ETHANEDIOL, ALANINE, Aspartate aminotransferase family protein, ... | | 著者 | Yang, L, Wang, H, Wei, D. | | 登録日 | 2022-08-03 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | | 主引用文献 | Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7QUW
 | | CVB3-3Cpro in complex with inhibitor MG-78 | | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, Protease 3C | | 著者 | Zhang, L, Hilgenfeld, R. | | 登録日 | 2022-01-19 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease.
Molecules, 27, 2022
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8GNA
 | | Structure of the SbCas7-11-crRNA-NTR complex | | 分子名称: | RAMP superfamily protein, RNA (32-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*U)-3'), ... | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-08-23 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Target RNA-guided protease activity in type III-E CRISPR-Cas system.
Nucleic Acids Res., 50, 2022
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8GU6
 | | Structure of the SbCas7-11-crRNA-NTR-Csx29 complex | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-09-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Target RNA-guided protease activity in type III-E CRISPR-Cas system.
Nucleic Acids Res., 50, 2022
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7QUB
 | | EV-A71-3Cpro in complex with inhibitor MG78 | | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, Protease 3C, SODIUM ION | | 著者 | El Kilani, H, Hilgenfeld, R. | | 登録日 | 2022-01-17 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease.
Molecules, 27, 2022
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