6AVO

Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes

Summary for 6AVO

• Entry DOI: 10.2210/pdb6avo/pdb
• EMDB information: 7010
• Descriptor: Proteasome subunit beta type-9, Proteasome subunit alpha type-2, Proteasome subunit beta type-1, ... (15 entities in total)
• Functional Keywords: inhibitor, complex, immunoproteasome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 28
• Total formula weight: 716690.06

Authors

Li, H.,Santos, R.,Bai, L. (deposition date: 2017-09-04, release date: 2017-12-06, Last modification date: 2024-03-13)

• Primary citation: Santos, R.L.A.,Bai, L.,Singh, P.K.,Murakami, N.,Fan, H.,Zhan, W.,Zhu, Y.,Jiang, X.,Zhang, K.,Assker, J.P.,Nathan, C.F.,Li, H.,Azzi, J.,Lin, G.; Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.; Nat Commun, 8:1692-1692, 2017; PubMed: 29167449; DOI: 10.1038/s41467-017-01760-5

Experimental method

ELECTRON MICROSCOPY (3.8 Å)