6AVO
Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F | Proteasome subunit beta type-9 | polymer | 199 | 21295.0 | 2 | UniProt (P28065) Pfam (PF00227) In PDB | Homo sapiens (Human) | Proteasome subunit beta type-6, Low molecular mass protein 2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, Proteasome chain 7, Proteasome subunit beta-1i, Really interesting new gene 12 protein |
| 2 | B, E | Proteasome subunit beta type-10 | polymer | 234 | 24674.2 | 2 | UniProt (P40306) Pfam (PF00227) Pfam (PF12465) In PDB | Homo sapiens (Human) | Proteasome subunit beta type-7, Low molecular mass protein 10, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1, Proteasome MECl-1, Proteasome subunit beta-2i |
| 3 | C, D | Proteasome subunit beta type-8 | polymer | 204 | 22685.6 | 2 | UniProt (P28062) Pfam (PF00227) In PDB | Homo sapiens (Human) | Proteasome subunit beta type-5, Low molecular mass protein 7, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13, Proteasome component C13, Proteasome subunit beta-5i, Really interesting new gene 10 protein |
| 4 | G, L | Proteasome subunit alpha type-1 | polymer | 263 | 29595.6 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain |
| 5 | H, M | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain |
| 6 | I, N | Proteasome subunit alpha type-7 | polymer | 248 | 27929.9 | 2 | UniProt (O14818) Pfam (PF00227) Pfam (PF10584) In PDB | Homo sapiens (Human) | Proteasome subunit RC6-1, Proteasome subunit XAPC7 |
| 7 | J, Q | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8 |
| 8 | K, R | Proteasome subunit alpha type-6 | polymer | 246 | 27432.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | 27 kDa prosomal protein, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain |
| 9 | O, Z | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L |
| 10 | P, b | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3 |
| 11 | S, X | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain |
| 12 | T, V | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I |
| 13 | U, Y | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) In PDB | Homo sapiens (Human) | Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain |
| 14 | W, a | Proteasome subunit beta type-4 | polymer | 219 | 24414.7 | 2 | UniProt (P28070) Pfam (PF00227) In PDB | Homo sapiens (Human) | 26 kDa prosomal protein, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain,Proteasome chain 3, HsN3 |
| 15 | C, D | N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamide | non-polymer | 542.7 | 2 | Chemie (BZ7) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 715604.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1085.3 | |
| All* | Total formula weight | 716690.1 |
