6AI6
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![BU of 6ai6 by Molmil](/molmil-images/mine/6ai6) | Crystal structure of SpCas9-NG | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | 著者 | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | 登録日 | 2018-08-21 | 公開日 | 2018-10-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Engineered CRISPR-Cas9 nuclease with expanded targeting space Science, 361, 2018
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8X5V
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![BU of 8x5v by Molmil](/molmil-images/mine/8x5v) | BlCas9-sgRNA-target DNA complex | 分子名称: | 1,2-ETHANEDIOL, BlCas9, CHLORIDE ION, ... | 著者 | Nakane, T, Nakagawa, R, Yamashita, K, Nishimasu, H, Nureki, O. | 登録日 | 2023-11-19 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and engineering of Brevibacillus laterosporus Cas9. Commun Biol, 7, 2024
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5B34
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![BU of 5b34 by Molmil](/molmil-images/mine/5b34) | Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles in Complex with Iodine-labeled Detergent HAD13a Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA | 分子名称: | 2,4,6-tris(iodanyl)-5-(octanoylamino)benzene-1,3-dicarboxylic acid, Bacteriorhodopsin, DECANE, ... | 著者 | Mizohata, E, Nakane, T. | 登録日 | 2016-02-10 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent Proc.Natl.Acad.Sci.USA, 113, 2016
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5B35
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![BU of 5b35 by Molmil](/molmil-images/mine/5b35) | Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA | 分子名称: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, Bacteriorhodopsin, DECANE, ... | 著者 | Mizohata, E, Nakane, T, Suzuki, M. | 登録日 | 2016-02-10 | 公開日 | 2016-11-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent Proc.Natl.Acad.Sci.USA, 113, 2016
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8WT7
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![BU of 8wt7 by Molmil](/molmil-images/mine/8wt7) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange locked state | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination Nature, 630, 2024
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8WT8
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![BU of 8wt8 by Molmil](/molmil-images/mine/8wt8) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction intermediate) | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination Nature, 630, 2024
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8WT6
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![BU of 8wt6 by Molmil](/molmil-images/mine/8wt6) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange state | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination Nature, 630, 2024
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8WT9
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![BU of 8wt9 by Molmil](/molmil-images/mine/8wt9) | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction resolution) | 分子名称: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishimasu, H. | 登録日 | 2023-10-18 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of bridge RNA-guided recombination Nature, 630, 2024
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8JF5
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![BU of 8jf5 by Molmil](/molmil-images/mine/8jf5) | Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440 | 分子名称: | 4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Fukushima, H, Machida, T, Yamashita, S, Suzuki, T. | 登録日 | 2023-05-17 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer To Be Published
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7XHT
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![BU of 7xht by Molmil](/molmil-images/mine/7xht) | Structure of the OgeuIscB-omega RNA-target DNA complex | 分子名称: | DNA (49-MER), DNA (5'-D(P*GP*AP*AP*GP*AP*AP*AP*AP*CP*CP*AP*T)-3'), LAURYL DIMETHYLAMINE-N-OXIDE, ... | 著者 | Kato, K, Okazaki, O, Isayama, Y, Ishikawa, J, Nishizawa, T, Nishimasu, H. | 登録日 | 2022-04-10 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Structure of the IscB-omega RNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9. Nat Commun, 13, 2022
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6IVX
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![BU of 6ivx by Molmil](/molmil-images/mine/6ivx) | Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. | 分子名称: | (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Doi, S, Adachi, T. | 登録日 | 2018-12-04 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. J. Med. Chem., 62, 2019
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5B0X
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5B6X
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![BU of 5b6x by Molmil](/molmil-images/mine/5b6x) | A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 760 ns after photoexcitation | 分子名称: | 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, DECANE, ... | 著者 | Royant, A, Nango, E, Nakane, T, Tanaka, T, Arima, T, Neutze, R, Iwata, S. | 登録日 | 2016-06-02 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A three-dimensional movie of structural changes in bacteriorhodopsin Science, 354, 2016
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5B6V
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![BU of 5b6v by Molmil](/molmil-images/mine/5b6v) | A three dimensional movie of structural changes in bacteriorhodopsin: resting state structure | 分子名称: | 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, DECANE, ... | 著者 | Nango, E, Royant, A, Nakane, T, Tanaka, T, Arima, T, Neutze, R, Iwata, S. | 登録日 | 2016-06-02 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A three-dimensional movie of structural changes in bacteriorhodopsin Science, 354, 2016
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5B6Y
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![BU of 5b6y by Molmil](/molmil-images/mine/5b6y) | A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 36.2 us after photoexcitation | 分子名称: | 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, DECANE, ... | 著者 | Royant, A, Nango, E, Nakane, T, Tanaka, T, Arima, T, Neutze, R, Iwata, S. | 登録日 | 2016-06-02 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A three-dimensional movie of structural changes in bacteriorhodopsin Science, 354, 2016
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5B6W
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![BU of 5b6w by Molmil](/molmil-images/mine/5b6w) | A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 16 ns after photoexcitation | 分子名称: | 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, DECANE, ... | 著者 | Royant, A, Nango, E, Nakane, T, Tanaka, T, Arima, T, Neutze, R, Iwata, S. | 登録日 | 2016-06-02 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A three-dimensional movie of structural changes in bacteriorhodopsin Science, 354, 2016
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5B6Z
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![BU of 5b6z by Molmil](/molmil-images/mine/5b6z) | A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 1.725 ms us after photoexcitation | 分子名称: | 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, DECANE, ... | 著者 | Royant, A, Nango, E, Nakane, T, Tanaka, T, Arima, T, Neutze, R, Iwata, S. | 登録日 | 2016-06-02 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A three-dimensional movie of structural changes in bacteriorhodopsin Science, 354, 2016
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8JBN
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![BU of 8jbn by Molmil](/molmil-images/mine/8jbn) | Vascular endothelial protein tyrosine phosphatase in complex with Cpd-1 | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-(1~{H}-indol-3-yl)-1,2-oxazole-3-carboxylic acid, ... | 著者 | Orita, T, Furuzono, T, Doi, S, Adachi, T. | 登録日 | 2023-05-09 | 公開日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques. Biochemistry, 62, 2023
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8JBY
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![BU of 8jby by Molmil](/molmil-images/mine/8jby) | Vascular endothelial protein tyrosine phosphatase in complex with Cpd-2 | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(hydroxymethyl)-5-(1-methylindol-3-yl)-1,2-oxazole-3-carboxylic acid, ... | 著者 | Orita, T, Furuzono, T, Doi, S, Adachi, T. | 登録日 | 2023-05-10 | 公開日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques. Biochemistry, 62, 2023
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4PK5
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![BU of 4pk5 by Molmil](/molmil-images/mine/4pk5) | Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with Amg-1 | 分子名称: | Indoleamine 2,3-dioxygenase 1, N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kohno, T, Tojo, S, Ishii, T. | 登録日 | 2014-05-13 | 公開日 | 2014-09-03 | 最終更新日 | 2020-01-29 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. Acs Med.Chem.Lett., 5, 2014
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6IS6
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![BU of 6is6 by Molmil](/molmil-images/mine/6is6) | Crystal structure of Thermoplasmatales archaeon heliorhodopsin | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, RETINAL, heliorhodopsin | 著者 | Shihoya, W, Yamashita, K, Nureki, O. | 登録日 | 2018-11-15 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of heliorhodopsin. Nature, 574, 2019
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4PAE
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![BU of 4pae by Molmil](/molmil-images/mine/4pae) | Crystal structure of catalase-peroxidase (KatG) W78F mutant from Synechococcus elongatus PCC7942 | 分子名称: | Catalase-peroxidase, HEME B/C, SODIUM ION, ... | 著者 | Kamachi, S, Wada, K, Tada, T. | 登録日 | 2014-04-08 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.206 Å) | 主引用文献 | Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. Febs Lett., 589, 2015
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1J0J
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1J0I
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1J0H
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![BU of 1j0h by Molmil](/molmil-images/mine/1j0h) | |