8JF5

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440

Summary for 8JF5

• Entry DOI: 10.2210/pdb8jf5/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: histone demethylase, flavoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 90660.24

Authors

Fukushima, H.,Machida, T.,Yamashita, S.,Suzuki, T. (deposition date: 2023-05-17, release date: 2024-05-22)

• Primary citation: Machida, T.,Tsukioka, S.,Gong, Y.,Onodera, A.,Nakayama, A.,Hashimoto, N.,Ohkubo, S.,Tanaka, T.; TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.2 Å)