8JF5
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 663 | 73709.3 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 2 | B (B) | REST corepressor 1 | polymer | 135 | 15505.7 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (human) | Protein CoREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (A) | 4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile | non-polymer | 475.5 | 1 | Chemie (UEU) |
Sequence modifications
A: 172 - 833 (UniProt: O60341)
B: 308 - 440 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 306 | - | initiating methionine |
| Gly 307 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89215.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1445.3 | |
| All* | Total formula weight | 90660.2 |
