5B0X

Crystal structure of the CK2a/benzoic acid derivative complex

Summary for 5B0X

Entry DOI	10.2210/pdb5b0x/pdb
Descriptor	Casein kinase II subunit alpha, 4-[2-[(4-methoxyphenyl)carbonylamino]-1,3-thiazol-5-yl]benzoic acid (3 entities in total)
Functional Keywords	inhibitor, complex, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40832.57
Authors	Kinoshita, T.,Nakanishi, I. (deposition date: 2015-11-13, release date: 2016-03-30, Last modification date: 2023-11-08)
Primary citation	Ohno, H.,Minamiguchi, D.,Nakamura, S.,Shu, K.,Okazaki, S.,Honda, M.,Misu, R.,Moriwaki, H.,Nakanishi, S.,Oishi, S.,Kinoshita, T.,Nakanishi, I.,Fujii, N. Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors Bioorg.Med.Chem., 24:1136-1141, 2016 Cited by PubMed: 26850376 DOI: 10.1016/j.bmc.2016.01.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation