6OX5
| A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine | 分子名称: | 1,2-ETHANEDIOL, Actin Peptide, Actin-histidine N-methyltransferase, ... | 著者 | Horton, J.R, Dai, S, Cheng, X. | 登録日 | 2019-05-13 | 公開日 | 2019-08-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
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6OX2
| SETD3in Complex with an Actin Peptide with the Target Histidine Fully Methylated | 分子名称: | 1,2-ETHANEDIOL, Actin Peptide, GLYCEROL, ... | 著者 | Horton, J.R, Dai, S, Cheng, X. | 登録日 | 2019-05-13 | 公開日 | 2019-08-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.089 Å) | 主引用文献 | Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
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7BW6
| Varicella-zoster virus capsid | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | 著者 | Wang, P.Y, Qi, J.X, Liu, C.C, Sun, J.Q. | 登録日 | 2020-04-13 | 公開日 | 2020-09-23 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of the varicella-zoster virus A-capsid. Nat Commun, 11, 2020
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6P5S
| HIPK2 kinase domain bound to CX-4945 | 分子名称: | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Homeodomain-interacting protein kinase 2 | 著者 | Agnew, C, Liu, L, Jura, N. | 登録日 | 2019-05-30 | 公開日 | 2019-07-31 | 最終更新日 | 2019-09-25 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. J.Biol.Chem., 294, 2019
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4WIV
| Crystal Structure of the first bromodomain of human BRD4 in complex with a novel inhibitor UMB32 (N-TERT-BUTYL-2-[4-(3,5-DIMETHYL-1,2-OXAZOL-4-YL) PHENYL]IMIDAZO[1,2-A]PYRAZIN-3-AMINE) | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... | 著者 | Xu, X, Blacklow, S. | 登録日 | 2014-09-26 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Biased multicomponent reactions to develop novel bromodomain inhibitors. J.Med.Chem., 57, 2014
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8BAY
| Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate | 分子名称: | (R)-3-butyl-2-oxopentanedioic acid, (S)-3-butyl-2-oxopentanedioic acid, CALCIUM ION, ... | 著者 | Rabe, P, Schofield, C.J, Reinbold, R, Brewitz, L. | 登録日 | 2022-10-12 | 公開日 | 2022-11-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2. J.Biol.Chem., 299, 2023
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6VC8
| Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Tran, T.H, Davies, D.R, Edwards, T.E, Simanshu, D.K. | 登録日 | 2019-12-20 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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6ZJF
| Crystal structure of STK17B (DRAK2) in complex with AP-229 | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | 著者 | Chaikuad, A, Picado, A, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-06-28 | 公開日 | 2020-07-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
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7AKG
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1H3H
| Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain | 分子名称: | GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2 | 著者 | Liu, Q, Berry, D, Nash, P, Pawson, T, McGlade, C.J, Li, S.S. | 登録日 | 2002-09-03 | 公開日 | 2003-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition Mol.Cell, 11, 2003
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6Y6H
| Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-26 | 公開日 | 2020-03-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
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6Y6F
| Crystal structure of STK17B (DRAK2) in complex with PKIS43 | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-26 | 公開日 | 2020-03-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
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4TQ6
| Structure of a UbiA homolog from Archaeoglobus fulgidus bound to Cd2+ | 分子名称: | CADMIUM ION, prenyltransferase | 著者 | Huang, H, Levin, E.J, Bai, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2014-06-10 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.0678 Å) | 主引用文献 | Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1. Plos Biol., 12, 2014
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4TQ5
| Structure of a UbiA homolog from Archaeoglobus fulgidus | 分子名称: | octyl beta-D-glucopyranoside, prenyltransferase | 著者 | Huang, H, Levin, E.J, Bai, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2014-06-10 | 公開日 | 2014-07-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.2023 Å) | 主引用文献 | Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1. Plos Biol., 12, 2014
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4TQ4
| Structure of a UbiA homolog from Archaeoglobus fulgidus bound to DMAPP and Mg2+ | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, prenyltransferase | 著者 | Huang, H, Levin, E.J, Bai, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2014-06-10 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5025 Å) | 主引用文献 | Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1. Plos Biol., 12, 2014
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4TQ3
| Structure of a UbiA homolog from Archaeoglobus fulgidus bound to GPP and Mg2+ | 分子名称: | GERANYL DIPHOSPHATE, MAGNESIUM ION, Prenyltransferase | 著者 | Huang, H, Levin, E.J, Bai, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2014-06-10 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4076 Å) | 主引用文献 | Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1. Plos Biol., 12, 2014
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6GSY
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | GLUTATHIONE, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3 | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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6GSU
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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6GSX
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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6GSW
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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6GSV
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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6GST
| FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | 分子名称: | GLUTATHIONE, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3 | 著者 | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | 登録日 | 1996-01-26 | 公開日 | 1996-11-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase. Biochemistry, 35, 1996
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4EQ8
| Crystal structure of PA1844 from Pseudomonas aeruginosa PAO1 | 分子名称: | GLYCEROL, Putative uncharacterized protein | 著者 | Shang, G, Li, N, Zhang, J, Lu, D, Yu, Q, Zhao, Y, Liu, X, Xu, S, Gu, L. | 登録日 | 2012-04-18 | 公開日 | 2012-09-12 | 最終更新日 | 2013-07-24 | 実験手法 | X-RAY DIFFRACTION (1.392 Å) | 主引用文献 | Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem.J., 448, 2012
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4EQA
| Crystal structure of PA1844 in complex with PA1845 from Pseudomonas aeruginosa PAO1 | 分子名称: | Putative uncharacterized protein | 著者 | Shang, G, Li, N, Zhang, J, Lu, D, Yu, Q, Zhao, Y, Liu, X, Xu, S, Gu, L. | 登録日 | 2012-04-18 | 公開日 | 2012-09-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem.J., 448, 2012
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8W2O
| Yeast U1 snRNP with humanized U1C Zinc-Finger domain | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... | 著者 | Shi, S.S, Kuang, Z.L, Zhao, R. | 登録日 | 2024-02-20 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. Rna, 2024
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