8BAY
Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate
Summary for 8BAY
| Entry DOI | 10.2210/pdb8bay/pdb |
| Related | 7PJM 7PJN |
| Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
| Functional Keywords | oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 147422.41 |
| Authors | Rabe, P.,Schofield, C.J.,Reinbold, R.,Brewitz, L. (deposition date: 2022-10-12, release date: 2022-11-02, Last modification date: 2024-02-07) |
| Primary citation | Liu, X.,Reinbold, R.,Liu, S.,Herold, R.A.,Rabe, P.,Duclos, S.,Yadav, R.B.,Abboud, M.I.,Thieffine, S.,Armstrong, F.A.,Brewitz, L.,Schofield, C.J. Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2. J.Biol.Chem., 299:102873-102873, 2023 Cited by PubMed: 36621625DOI: 10.1016/j.jbc.2023.102873 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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