7PJM

Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and Ca2+/2-Oxoglutarate

Summary for 7PJM

Entry DOI	10.2210/pdb7pjm/pdb
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, GLYCEROL, ... (7 entities in total)
Functional Keywords	oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	146661.74
Authors	Reinbold, R.,Rabe, P.,Abboud, M.I.,Schofield, C.J. (deposition date: 2021-08-24, release date: 2022-07-13, Last modification date: 2024-01-31)
Primary citation	Reinbold, R.,Hvinden, I.C.,Rabe, P.,Herold, R.A.,Finch, A.,Wood, J.,Morgan, M.,Staudt, M.,Clifton, I.J.,Armstrong, F.A.,McCullagh, J.S.O.,Redmond, J.,Bardella, C.,Abboud, M.I.,Schofield, C.J. Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. Nat Commun, 13:4785-4785, 2022 Cited by PubMed: 35970853 DOI: 10.1038/s41467-022-32436-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation