3STV
 
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2FAI
 | | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-2M and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide | | 分子名称: | 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 | | 著者 | Rajan, S.S, Hsieh, R.W, Sharma, S.K, Greene, G.L. | | 登録日 | 2005-12-07 | | 公開日 | 2006-05-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
J.Biol.Chem., 281, 2006
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2B1V
 | | Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide | | 分子名称: | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 | | 著者 | Rajan, S.S, Hsieh, R.W, Sharma, S.K, Greene, G.L. | | 登録日 | 2005-09-16 | | 公開日 | 2006-05-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
J.Biol.Chem., 281, 2006
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2PVX
 | | NMR and X-ray Analysis of Structural Additivity in Metal Binding Site-Swapped Hybrids of Rubredoxin | | 分子名称: | Rubredoxin, ZINC ION | | 著者 | Wang, L, LeMaster, D.M, Hernandez, G, Li, H. | | 登録日 | 2007-05-10 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | | 主引用文献 | NMR and X-ray analysis of structural additivity in metal binding site-swapped hybrids of rubredoxin
Bmc Struct.Biol., 7, 2007
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3EOB
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3EOA
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3GIZ
 | | Crystal structure of the Fab fragment of anti-CD20 antibody Ofatumumab | | 分子名称: | Fab fragment of anti-CD20 antibody Ofatumumab, heavy chain, light chain, ... | | 著者 | Du, J, Yang, H, Ding, J. | | 登録日 | 2009-03-07 | | 公開日 | 2009-05-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20
Mol.Immunol., 46, 2009
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3EO9
 | | Crystal structure the Fab fragment of Efalizumab | | 分子名称: | Efalizumab Fab fragment, heavy chain, light chain | | 著者 | Li, S, Ding, J. | | 登録日 | 2008-09-26 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.
Proc.Natl.Acad.Sci.USA, 106, 2009
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7CPV
 | | Cryo-EM structure of 80S ribosome from mouse testis | | 分子名称: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | | 著者 | Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. | | 登録日 | 2020-08-08 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
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5WUE
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | SULFATE ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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5WUD
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | MAGNESIUM ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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5WUC
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | SODIUM ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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6M17
 | | The 2019-nCoV RBD/ACE2-B0AT1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Xia, L, Guo, Y.Y, Zhou, Q. | | 登録日 | 2020-02-24 | | 公開日 | 2020-03-11 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
Science, 367, 2020
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8HOG
 | | Crystal structure of Bcl-2 in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8HOH
 | | Crystal structure of Bcl-2 G101V in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8HOI
 | | Crystal structure of Bcl-2 D103Y in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8ID6
 | | Cryo-EM structure of the oleic acid bound GPR120-Gi complex | | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID4
 | | Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID9
 | | Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID3
 | | Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | | 分子名称: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID8
 | | Cryo-EM structure of the TUG891 bound GPR120-Gi complex | | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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3L1N
 | | Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid | | 分子名称: | Cell wall antigen, PALMITIC ACID | | 著者 | Liao, S, Tung, E.T, Zheng, W, Chong, K, Xu, Y, Bartlam, M, Rao, Z, Yuen, K.Y. | | 登録日 | 2009-12-14 | | 公開日 | 2010-01-05 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein.
J.Biol.Chem., 285, 2010
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6J56
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5EOF
 | | Crystal structure of OPTN NTD and TBK1 CTD complex | | 分子名称: | Optineurin, Serine/threonine-protein kinase TBK1 | | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | | 登録日 | 2015-11-10 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
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5EP6
 | | The crystal structure of NAP1 in complex with TBK1 | | 分子名称: | 5-azacytidine-induced protein 2, GLYCEROL, Serine/threonine-protein kinase TBK1 | | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | | 登録日 | 2015-11-11 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
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