3TC7
| Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62. | 分子名称: | ACETIC ACID, Indole-3-glycerol phosphate synthase, PHOSPHATE ION | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-08-08 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol., 426, 2014
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3TC6
| Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR63. | 分子名称: | DI(HYDROXYETHYL)ETHER, Indole-3-glycerol phosphate synthase, PHOSPHATE ION | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-08-08 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol., 426, 2014
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1XBT
| Crystal Structure of Human Thymidine Kinase 1 | 分子名称: | MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, Thymidine kinase, ... | 著者 | Welin, M, Kosinska, U, Mikkelsen, N.E, Carnrot, C, Zhu, C, Wang, L, Eriksson, S, Munch-Petersen, B, Eklund, H. | 登録日 | 2004-08-31 | 公開日 | 2004-12-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of thymidine kinase 1 of human and mycoplasmic origin Proc.Natl.Acad.Sci.Usa, 101, 2004
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1XR1
| Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Qian, K.C, Wang, L, Hickey, E.R, Studts, J, Barringer, K, Peng, C, Kronkaitis, A, Li, J, White, A, Mische, S, Farmer, B. | 登録日 | 2004-10-13 | 公開日 | 2004-11-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase. J.Biol.Chem., 280, 2005
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1ZOL
| native beta-PGM | 分子名称: | MAGNESIUM ION, beta-phosphoglucomutase | 著者 | Zhang, G, Tremblay, L.W, Dai, J, Wang, L, Dunaway-Mariano, D, Allen, K.N. | 登録日 | 2005-05-13 | 公開日 | 2005-08-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis Biochemistry, 44, 2005
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1YGH
| HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE | 分子名称: | GLYCEROL, PROTEIN (TRANSCRIPTIONAL ACTIVATOR GCN5) | 著者 | Trievel, R.C, Rojas, J.R, Sterner, D.E, Venkataramani, R, Wang, L, Zhou, J, Allis, C.D, Berger, S.L, Marmorstein, R. | 登録日 | 1999-05-27 | 公開日 | 1999-08-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. Proc.Natl.Acad.Sci.USA, 96, 1999
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1Y6A
| Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | 分子名称: | N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE, Vascular endothelial growth factor receptor 2 | 著者 | Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. | 登録日 | 2004-12-05 | 公開日 | 2005-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005
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1YWN
| Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine | 分子名称: | N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA, Vascular endothelial growth factor receptor 2 | 著者 | Miyazaki, Y, Matsunaga, S, Tang, J, Maeda, Y, Nakano, M, Philippe, R.J, Shibahara, M, Liu, W, Sato, H, Wang, L, Nolte, R.T. | 登録日 | 2005-02-18 | 公開日 | 2005-08-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors Bioorg.Med.Chem.Lett., 15, 2005
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1Y6B
| Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | 分子名称: | N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE, Vascular endothelial growth factor receptor 2 | 著者 | Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. | 登録日 | 2004-12-05 | 公開日 | 2005-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005
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7WT9
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7WT7
| SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 9A8, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2022-02-04 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD. Cell Discov, 8, 2022
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7WT8
| SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 9A8, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2022-02-04 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD. Cell Discov, 8, 2022
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1XQZ
| Crystal Structure of hPim-1 kinase at 2.1 A resolution | 分子名称: | Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Qian, K.C, Wang, L, Hickey, E.R, Studts, J, Barringer, K, Peng, C, Kronkaitis, A, Li, J, White, A, Mische, S, Farmer, B. | 登録日 | 2004-10-13 | 公開日 | 2004-11-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase. J.Biol.Chem., 280, 2005
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6A2I
| Architectural roles of Cren7 in folding crenarchaeal chromatin filament | 分子名称: | Chromatin protein Cren7, DNA (5'-D(*CP*GP*TP*AP*GP*CP*TP*AP*AP*TP*TP*AP*GP*CP*TP*AP*CP*G)-3') | 著者 | Zhang, Z.F, Zhao, M.H, Chen, Y.Y, Wang, L, Dong, Y.H, Gong, Y, Huang, L. | 登録日 | 2018-06-11 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Architectural roles of Cren7 in folding crenarchaeal chromatin filament. Mol. Microbiol., 111, 2019
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7JVQ
| Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein | 分子名称: | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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7JVP
| Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein | 分子名称: | (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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7JV5
| Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein | 分子名称: | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-20 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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7JVR
| Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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4Z2B
| The structure of human PDE12 residues 161-609 in complex with GSK3036342A | 分子名称: | 1,2-ETHANEDIOL, 2',5'-phosphodiesterase 12, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Nolte, R.T, Wisely, B, Wang, L, Wood, E.R. | 登録日 | 2015-03-29 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J.Biol.Chem., 290, 2015
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4Z0V
| The structure of human PDE12 residues 161-609 | 分子名称: | 2',5'-phosphodiesterase 12, GLYCEROL, MAGNESIUM ION | 著者 | Nolte, R.T, Wisely, B, Wang, L, Wood, E.R. | 登録日 | 2015-03-26 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J.Biol.Chem., 290, 2015
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3JCM
| Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP | 分子名称: | 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... | 著者 | Wan, R, Yan, C, Bai, R, Wang, L, Huang, M, Wong, C.C, Shi, Y. | 登録日 | 2015-12-23 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis Science, 351, 2016
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4LNY
| Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR422 | 分子名称: | CADMIUM ION, CHLORIDE ION, Engineered Protein OR422 | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Sahdev, S, Xiao, R, Maglaqui, M, Kogan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-07-12 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.929 Å) | 主引用文献 | Crystal Structure of Engineered Protein OR422. To be Published
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4LT9
| Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR404 | 分子名称: | Engineered Protein OR404 | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Sahdev, S, Xiao, R, Kogan, S, Maglaqui, M, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-07-23 | 公開日 | 2013-08-14 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structure of Engineered Protein OR404. To be Published
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4E8C
| Crystal structure of streptococcal beta-galactosidase in complex with galactose | 分子名称: | GLYCEROL, Glycosyl hydrolase, family 35, ... | 著者 | Cheng, W, Wang, L, Bai, X.H, Jiang, Y.L, Li, Q, Yu, G, Zhou, C.Z, Chen, Y.X. | 登録日 | 2012-03-20 | 公開日 | 2012-05-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural insights into the substrate specificity of Streptococcus pneumoniae beta (1,3)-galactosidase BgaC J.Biol.Chem., 287, 2012
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7R0T
| Crystal structure of exonuclease ExnV1 | 分子名称: | CHLORIDE ION, Exonuclease ExnV1, MAGNESIUM ION, ... | 著者 | Welin, M, Svensson, A, Hakansson, M, Al-Karadaghi, S, Jasilionis, A, Linares-Pasten, J.A, Wang, L, Nordberg Karlsson, E, Ahlqvist, J. | 登録日 | 2022-02-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | Crystal structure of DNA polymerase I from Thermus phage G20c. Acta Crystallogr D Struct Biol, 78, 2022
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