1XR1

Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution

Summary for 1XR1

Entry DOI	10.2210/pdb1xr1/pdb
Related	1XQZ
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	protein kinase fold, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34806.71
Authors	Qian, K.C.,Wang, L.,Hickey, E.R.,Studts, J.,Barringer, K.,Peng, C.,Kronkaitis, A.,Li, J.,White, A.,Mische, S.,Farmer, B. (deposition date: 2004-10-13, release date: 2004-11-09, Last modification date: 2024-02-14)
Primary citation	Qian, K.C.,Wang, L.,Hickey, E.R.,Studts, J.,Barringer, K.,Peng, C.,Kronkaitis, A.,Li, J.,White, A.,Mische, S.,Farmer, B. Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase. J.Biol.Chem., 280:6130-6137, 2005 Cited by PubMed: 15525646 DOI: 10.1074/jbc.M409123200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation