7DD5
 
 | | Structure of Calcium-Sensing Receptor in complex with NPS-2143 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ... | | 著者 | Wen, T.L, Yang, X, Shen, Y.Q. | | 登録日 | 2020-10-27 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-06-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Sci Adv, 7, 2021
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7DD6
 | | Structure of Ca2+/L-Trp-bonnd Calcium-Sensing Receptor in active state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wen, T.L, Yang, X, Shen, Y.Q. | | 登録日 | 2020-10-27 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-06-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Sci Adv, 7, 2021
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8IP4
 | | Cryo-EM structure of hMRS-highEDTA | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2023-03-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP5
 | | Cryo-EM structure of hMRS2-lowEDTA | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2023-03-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP6
 | | Cryo-EM structure of hMRS2-rest | | 分子名称: | CHLORIDE ION, Magnesium transporter MRS2 homolog, mitochondrial | | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2023-03-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP3
 | | Cryo-EM structure of hMRS2-Mg | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2023-03-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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6LPI
 | | Crystal Structure of AHAS holo-enzyme | | 分子名称: | Acetolactate synthase isozyme 1 large subunit, Acetolactate synthase isozyme 1 small subunit, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Zhang, Y, Yang, X, Xi, Z, Shen, Y. | | 登録日 | 2020-01-10 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.849 Å) | | 主引用文献 | Molecular architecture of the acetohydroxyacid synthase holoenzyme.
Biochem.J., 477, 2020
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7WNX
 | | Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs | | 分子名称: | N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide, Trehalose monomycolate exporter MmpL3 | | 著者 | Zhang, B, Hu, T, Yang, X, Liu, F, Rao, Z. | | 登録日 | 2022-01-20 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3.
Structure, 30, 2022
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8JI8
 | | Crystal Structure of Prophenoloxidase PPO6 chimeric mutant (F215EASNRAIVD224 to G215DGPDSVVR223) from Aedes aegypti | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (II) ION, ... | | 著者 | Zhu, X, Zhang, L, Yang, X, Bao, P, Ren, D, Han, Q. | | 登録日 | 2023-05-26 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mosquitoes have evolved two types of prophenoloxidases
To Be Published
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8JIB
 | | Crystal Structure of Prophenoloxidase PPO6 from Aedes aegypti | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, TK receptor | | 著者 | Zhu, X, Zhang, L, Yang, X, Bao, P, Ren, D, Han, Q. | | 登録日 | 2023-05-26 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Mosquitoes have evolved two types of prophenoloxidases
To Be Published
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7Y7J
 | | SARS-CoV-2 S trimer in complex with 1F Fab | | 分子名称: | 1F VH, 1F VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, S, Liu, F, Yang, X, Zhong, G. | | 登録日 | 2022-06-22 | | 公開日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | A core epitope targeting antibody of SARS-CoV-2.
Protein Cell, 14, 2023
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7Y7K
 | | SARS-CoV-2 RBD in complex with 1F Fab | | 分子名称: | 1F VH, 1F VL, Spike protein S1 | | 著者 | Zhao, S, Liu, F, Yang, X, Zhong, G. | | 登録日 | 2022-06-22 | | 公開日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | A core epitope targeting antibody of SARS-CoV-2.
Protein Cell, 14, 2023
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7DSC
 | | CALHM1 open state with disordered CTH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2020-12-30 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.
J.Biol.Chem., 298, 2022
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7DSD
 | | CALHM1 close state with disordered CTH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2020-12-30 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.
J.Biol.Chem., 298, 2022
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7DSE
 | | CALHM1 close state with ordered CTH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2020-12-30 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.
J.Biol.Chem., 298, 2022
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7F01
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6LAE
 | | Crystal structure of the DNA-binding domain of human XPA in complex with DNA | | 分子名称: | DNA (5'-D(P*GP*CP*AP*TP*CP*TP*CP*GP*CP*CP*T)-3'), DNA (5'-D(P*TP*GP*GP*CP*GP*AP*GP*AP*TP*GP*C)-3'), DNA repair protein complementing XP-A cells, ... | | 著者 | Lian, F.M, Yang, X, Jiang, Y.L, Yang, F, Li, C, Yang, W, Qian, C. | | 登録日 | 2019-11-12 | | 公開日 | 2020-02-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA.
Int.J.Biol.Macromol., 148, 2020
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7EHL
 | | Cryo-EM structure of human ABCB8 transporter in nucleotide binding state | | 分子名称: | CHOLESTEROL, MAGNESIUM ION, Mitochondrial potassium channel ATP-binding subunit, ... | | 著者 | Li, S.J, Yang, X, Shen, Y.Q. | | 登録日 | 2021-03-29 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.
Biochem.Biophys.Res.Commun., 557, 2021
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6LYG
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5Z9Y
 | | Crystal structure of Mycobacterium tuberculosis thiazole synthase (ThiG) complexed with DXP | | 分子名称: | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, Thiazole synthase | | 著者 | Zhang, J, Zhang, B, Zhao, Y, Yang, X, Huang, M, Cui, P, Zhang, W, Li, J, Zhang, Y. | | 登録日 | 2018-02-05 | | 公開日 | 2018-04-11 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG).
Biochem. Biophys. Res. Commun., 497, 2018
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7Y1Q
 | | 5.0 angstrom cryo-EM structure of transmembrane regions of mouse Basigin/MCT1 in complex with antibody 6E7F1 | | 分子名称: | Isoform 2 of Basigin, Monocarboxylate transporter 1 | | 著者 | Zhang, H, Yang, X, Xue, Y, Huang, Y, Mo, X, Zhang, H, Li, N, Gao, N, Li, X, Wang, S, Gao, Y, Liao, J. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (5.03 Å) | | 主引用文献 | Allosteric modulation of monocarboxylate transporters 1 and 4 by targeting their chaperon Basigin-2
To Be Published
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7Y1B
 | | 3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1 | | 分子名称: | Heavy chain of 6E7F1, Isoform 2 of Basigin, Light chain of 6E7F1 | | 著者 | Zhang, H, Yang, X, Xue, Y, Huang, Y, Mo, X, Zhang, H, Li, N, Gao, N, Li, X, Wang, S, Gao, Y, Liao, J. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Allosteric modulation of monocarboxylate transporters 1 and 4 by targeting their chaperon Basigin
To Be Published
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7BVV
 | | Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 | | 分子名称: | Peroxiredoxin AHP1, Thioredoxin-2 | | 著者 | Lian, F.M, Jiang, Y.L, Yang, W, Yang, X. | | 登録日 | 2020-04-11 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle.
Int.J.Biol.Macromol., 161, 2020
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9EZG
 | | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((4-((2-aminoethyl)(ethyl)amino)-3-(4H-1,2,4-triazol-4-yl)phenyl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | | 分子名称: | 1,2-ETHANEDIOL, 5-[[4-[2-azanylethyl(ethyl)amino]-3-(1,2,4-triazol-4-yl)phenyl]amino]-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, ... | | 著者 | Kraemer, A, Ong, H.W, Yang, X, Brown, J.W, Chang, E, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2024-04-12 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication.
J.Med.Chem., 67, 2024
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6BJ8
 | | TCR55 in complex with Pep20/HLA-B35 | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Jude, K.M, Sibener, L.V, Yang, X, Garcia, K.C. | | 登録日 | 2017-11-05 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
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