5Z9Y

Crystal structure of Mycobacterium tuberculosis thiazole synthase (ThiG) complexed with DXP

Summary for 5Z9Y

• Entry DOI: 10.2210/pdb5z9y/pdb
• Descriptor: Thiazole synthase, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE (3 entities in total)
• Functional Keywords: alpha-beta barrel, covalently bound, carbinolamine intermediate, biosynthetic protein, transferase
• Biological source: Mycobacterium tuberculosis H37Rv
• Cellular location: Cytoplasm : P9WG73
• Total number of polymer chains: 2
• Total formula weight: 52161.53

Authors

Zhang, J.,Zhang, B.,Zhao, Y.,Yang, X.,Huang, M.,Cui, P.,Zhang, W.,Li, J.,Zhang, Y. (deposition date: 2018-02-05, release date: 2018-04-11)

• Primary citation: Zhang, J.,Zhang, B.,Zhao, Y.,Yang, X.,Huang, M.,Cui, P.,Zhang, W.,Li, J.,Zhang, Y.; Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG).; Biochem. Biophys. Res. Commun., 497:214-219, 2018; PubMed: 29428731; DOI: 10.1016/j.bbrc.2018.02.056

Experimental method

X-RAY DIFFRACTION (1.48 Å)