5Z9Y
Crystal structure of Mycobacterium tuberculosis thiazole synthase (ThiG) complexed with DXP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 1902508 | cellular_component | 2-iminoacetate synthase complex |
| A | 1990107 | molecular_function | thiazole synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 1902508 | cellular_component | 2-iminoacetate synthase complex |
| B | 1990107 | molecular_function | thiazole synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue DXP A 301 |
| Chain | Residue |
| A | THR43 |
| A | LEU206 |
| A | ALA207 |
| A | SER208 |
| A | HOH424 |
| A | HOH456 |
| A | HOH495 |
| A | ASN71 |
| A | LYS98 |
| A | GLU100 |
| A | ILE158 |
| A | GLY159 |
| A | ASP184 |
| A | ALA185 |
| A | GLY186 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide DXP B 301 and LYS B 98 |
| Chain | Residue |
| B | THR43 |
| B | PRO70 |
| B | ASN71 |
| B | THR72 |
| B | VAL97 |
| B | LEU99 |
| B | GLU100 |
| B | LEU130 |
| B | ILE158 |
| B | GLY159 |
| B | ASP184 |
| B | ALA185 |
| B | GLY186 |
| B | LEU205 |
| B | LEU206 |
| B | ALA207 |
| B | SER208 |
| B | HOH429 |
| B | HOH457 |
| B | HOH459 |
| B | HOH490 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide DXP B 301 and LYS B 98 |
| Chain | Residue |
| B | THR43 |
| B | PRO70 |
| B | ASN71 |
| B | THR72 |
| B | VAL97 |
| B | LEU99 |
| B | GLU100 |
| B | LEU130 |
| B | ILE158 |
| B | GLY159 |
| B | ASP184 |
| B | ALA185 |
| B | GLY186 |
| B | LEU205 |
| B | LEU206 |
| B | ALA207 |
| B | SER208 |
| B | HOH429 |
| B | HOH457 |
| B | HOH459 |
| B | HOH490 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Schiff-base intermediate with DXP","evidences":[{"source":"HAMAP-Rule","id":"MF_00443","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00443","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
