7WNX
Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs
Summary for 7WNX
Entry DOI | 10.2210/pdb7wnx/pdb |
EMDB information | 32634 |
Descriptor | Trehalose monomycolate exporter MmpL3, N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide (2 entities in total) |
Functional Keywords | drug target, novel compound, mycobacterium tuberculosis, membrane protein |
Biological source | Mycolicibacterium smegmatis MC2 155 |
Total number of polymer chains | 1 |
Total formula weight | 110581.81 |
Authors | |
Primary citation | Hu, T.,Yang, X.,Liu, F.,Sun, S.,Xiong, Z.,Liang, J.,Yang, X.,Wang, H.,Yang, X.,Guddat, L.W.,Yang, H.,Rao, Z.,Zhang, B. Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30:1395-1402.e4, 2022 Cited by PubMed: 35981536DOI: 10.1016/j.str.2022.07.009 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.36 Å) |
Structure validation
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