6LAE

Crystal structure of the DNA-binding domain of human XPA in complex with DNA

Summary for 6LAE

• Entry DOI: 10.2210/pdb6lae/pdb
• Descriptor: DNA repair protein complementing XP-A cells, DNA (5'-D(P*GP*CP*AP*TP*CP*TP*CP*GP*CP*CP*T)-3'), DNA (5'-D(P*TP*GP*GP*CP*GP*AP*GP*AP*TP*GP*C)-3'), ... (5 entities in total)
• Functional Keywords: protein-dna complex, nucleotide excision repair, dna repair, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 41776.54

Authors

Lian, F.M.,Yang, X.,Jiang, Y.L.,Yang, F.,Li, C.,Yang, W.,Qian, C. (deposition date: 2019-11-12, release date: 2020-02-26, Last modification date: 2023-11-22)

• Primary citation: Lian, F.M.,Yang, X.,Jiang, Y.L.,Yang, F.,Li, C.,Yang, W.,Qian, C.; New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA.; Int.J.Biol.Macromol., 148:466-474, 2020; PubMed: 31962067; DOI: 10.1016/j.ijbiomac.2020.01.169

Experimental method

X-RAY DIFFRACTION (2.81 Å)