6LAE

Crystal structure of the DNA-binding domain of human XPA in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006289	biological_process	nucleotide-excision repair
B	0003684	molecular_function	damaged DNA binding
B	0006289	biological_process	nucleotide-excision repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS105
A	CYS108
A	CYS126
A	CYS129

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	CYS105
B	CYS108
B	CYS126
B	CYS129

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Functional Information from PROSITE/UniProt

site_id	PS00752
Number of Residues	25
Details	XPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC

Chain	Residue	Details
A	CYS105-CYS129

---

site_id	PS00753
Number of Residues	17
Details	XPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD

Chain	Residue	Details
A	LEU138-ASP154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Zinc finger: {"evidences":[{"source":"PubMed","id":"2234061","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D4U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16540648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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