3F1A
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3F19
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3F18
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4JL4
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2GA2
| h-MetAP2 complexed with A193400 | 分子名称: | 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | 著者 | Park, C. | 登録日 | 2006-03-07 | 公開日 | 2007-03-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg.Med.Chem.Lett., 16, 2006
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8F1I
| SigN RNA polymerase early-melted intermediate bound to mismatch fragment dhsU36mm1 (-12T) | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | 登録日 | 2022-11-05 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1J
| SigN RNA polymerase early-melted intermediate bound to mismatch DNA fragment dhsU36mm2 (-12A) | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | 登録日 | 2022-11-05 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1K
| SigN RNA polymerase early-melted intermediate bound to full duplex DNA fragment dhsU36 (-12T) | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | 登録日 | 2022-11-05 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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3N2V
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3N2U
| Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide | 分子名称: | CALCIUM ION, Macrophage metalloelastase, N-hydroxy-2-{[(4-methoxyphenyl)sulfonyl](2-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}ethyl)amino}acetamide, ... | 著者 | Calderone, V. | 登録日 | 2010-05-19 | 公開日 | 2010-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur.J.Med.Chem., 45, 2010
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2K8J
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2HU6
| Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor | 分子名称: | (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | 著者 | Mannino, C, Nievo, M, Machetti, F, Papakyriakou, A, Calderone, V, Fragai, M, Guarna, A. | 登録日 | 2006-07-26 | 公開日 | 2006-12-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors. Bioorg.Med.Chem., 14, 2006
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5T18
| Crystal structure of Bruton agammabulinemia tyrosine kinase complexed with BMS-986142 aka (2s)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | 分子名称: | 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide, Tyrosine-protein kinase BTK | 著者 | Muckelbauer, J.K. | 登録日 | 2016-08-18 | 公開日 | 2017-03-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. J. Med. Chem., 59, 2016
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2GIW
| SOLUTION STRUCTURE OF REDUCED HORSE HEART CYTOCHROME C, NMR, 40 STRUCTURES | 分子名称: | CYTOCHROME C, HEME C | 著者 | Banci, L, Bertini, I, Huber, J.G, Spyroulias, G.A, Turano, P. | 登録日 | 1998-06-25 | 公開日 | 1998-12-09 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of reduced horse heart cytochrome c. J.Biol.Inorg.Chem., 4, 1999
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1JEA
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8D14
| Helical ADP-Pi-F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D18
| Straight ADP-F-actin 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D15
| Bent ADP-F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D13
| Helical ADP-F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D17
| Straight ADP-F-actin 1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D16
| Bent ADP-Pi-F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-05-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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1FXR
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5VLK
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5VLA
| Short PCSK9 delta-P' complex with Fusion2 peptide | 分子名称: | CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-MET-PRO-TRP-ASN-LEU-VAL-ARG-ILE-GLY-LEU-LEU | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2017-04-25 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
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5VLP
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