3N2U
Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide
Summary for 3N2U
Entry DOI | 10.2210/pdb3n2u/pdb |
Related | 3F15 3F16 3F17 3N2V |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, extracellular matrix, glycoprotein, hydrolase, metal-inding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 1 |
Total formula weight | 18201.99 |
Authors | Calderone, V. (deposition date: 2010-05-19, release date: 2010-11-10, Last modification date: 2023-09-06) |
Primary citation | Attolino, E.,Calderone, V.,Dragoni, E.,Fragai, M.,Richichi, B.,Luchinat, C.,Nativi, C. Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur.J.Med.Chem., 45:5919-5925, 2010 Cited by PubMed: 20965620DOI: 10.1016/j.ejmech.2010.09.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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