3F16
Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-N-(3-hydroxy-1-nitroso-1-oxopropan-2-yl)-4-methoxybenzenesulfonamide
Summary for 3F16
Entry DOI | 10.2210/pdb3f16/pdb |
Related | 3F15 3F17 3F18 3F19 3F1A |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 18023.80 |
Authors | Calderone, V. (deposition date: 2008-10-27, release date: 2008-11-18, Last modification date: 2023-12-27) |
Primary citation | Bertini, I.,Calderone, V.,Fragai, M.,Giachetti, A.,Loconte, M.,Luchinat, C.,Maletta, M.,Nativi, C.,Yeo, K.J. Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases. J.Am.Chem.Soc., 129:2466-2475, 2007 Cited by PubMed: 17269766DOI: 10.1021/ja065156z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.16 Å) |
Structure validation
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