5VLP
PCSK9 complex with LDLR antagonist peptide and Fab7G7
Summary for 5VLP
Entry DOI | 10.2210/pdb5vlp/pdb |
Related | 5VL7 5VLA 5VLH 5VLK 5VLL |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Fab7G7 heavy chain, Fab7G7 light chain, ... (6 entities in total) |
Functional Keywords | immunoglobulin, proprotein convertase, antagonist, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 125318.69 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-11-15) |
Primary citation | Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24:848-856, 2017 Cited by PubMed: 28825733DOI: 10.1038/nsmb.3453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report