5VLP

PCSK9 complex with LDLR antagonist peptide and Fab7G7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proprotein convertase subtilisin/kexin type 9	polymer	700	75566.5	1	UniProt (Q8NBP7) Pfam (PF05922) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	H	Fab7G7 heavy chain	polymer	223	24117.9	1		Mus musculus (Mouse)
3	L	Fab7G7 light chain	polymer	214	23659.1	1	UniProt (A0A0U5BC76) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (Mouse)
4	Z	LDLR antagonist peptide	polymer	17	1929.3	1		synthetic construct
5	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 1 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ile 474	Val 474	variant
Glu 670	Gly 670	variant
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag
His 699	-	expression tag
His 700	-	expression tag

L: 1 - 126 (PDB: 5VLP)
L: 107 - 214 (UniProt: A0A0U5BC76)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	125272.7
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	125318.7

*Water molecules are not included.