3N2V

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(N-hydroxyethyl)biphenyl-4-ylsulfonamido)acetamide

Summary for 3N2V

Entry DOI	10.2210/pdb3n2v/pdb
Related	3F15 3F16 3F17 3N2U
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, extracellular matrix, glycoprotein, hydrolase, metal-inding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	18085.92
Authors	Calderone, V. (deposition date: 2010-05-19, release date: 2010-11-10, Last modification date: 2023-09-06)
Primary citation	Attolino, E.,Calderone, V.,Dragoni, E.,Fragai, M.,Richichi, B.,Luchinat, C.,Nativi, C. Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur.J.Med.Chem., 45:5919-5925, 2010 Cited by PubMed: 20965620 DOI: 10.1016/j.ejmech.2010.09.057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation