8KEQ
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8KEJ
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8KEH
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7EU8
| Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate | 分子名称: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Zhang, T, Zhang, Y, Zhu, S. | 登録日 | 2021-05-16 | 公開日 | 2021-07-28 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structural basis of ketamine action on human NMDA receptors. Nature, 596, 2021
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7EU7
| Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate | 分子名称: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, Y, Zhang, T, Zhu, S. | 登録日 | 2021-05-16 | 公開日 | 2021-08-04 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of ketamine action on human NMDA receptors. Nature, 596, 2021
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7F0M
| Crystal Structure of human Pin1 complexed with a potent covalent inhibitor | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 8-(2-chloranylethanoyl)-4-[(5-naphthalen-1-ylfuran-2-yl)methyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Liu, L, Li, J. | 登録日 | 2021-06-05 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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2GLM
| Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with Compound 2 | 分子名称: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 2-CHLORO-5-(5-{(E)-[(2Z)-3-(2-METHOXYETHYL)-4-OXO-2-(PHENYLIMINO)-1,3-THIAZOLIDIN-5-YLIDENE]METHYL}-2-FURYL)BENZOIC ACID, BENZAMIDINE, ... | 著者 | Zhang, L, Liu, W, Shen, X, Jiang, H. | 登録日 | 2006-04-05 | 公開日 | 2007-03-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J.Biol.Chem., 283, 2008
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5W18
| Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide | 分子名称: | 9V7-PHE-SER-PRO-YCP-ALA-MP8, ATP-dependent Clp protease proteolytic subunit | 著者 | Lee, R.E, Griffith, E.C. | 登録日 | 2017-06-02 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Ureadepsipeptides as ClpP Activators. Acs Infect Dis., 2019
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3UOB
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3UO7
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7V7L
| Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | 著者 | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | 登録日 | 2021-08-21 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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7V7W
| Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | 著者 | Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D. | 登録日 | 2021-08-21 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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8J5J
| The crystal structure of bat coronavirus RsYN04 RBD bound to the antibody S43 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nano antibody S43 | 著者 | Zhao, R.C, Niu, S, Han, P, Qi, J.X, Gao, G.F, Wang, Q.H. | 登録日 | 2023-04-23 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cross-species recognition of bat coronavirus RsYN04 and cross-reaction of SARS-CoV-2 antibodies against the virus. Zool.Res., 44, 2023
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8JRN
| Structure of E6AP-E6 complex in Att1 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRQ
| Structure of E6AP-E6 complex in Det1 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRP
| Structure of E6AP-E6 complex in Att3 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRR
| Structure of E6AP-E6 complex in Det2 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRO
| Structure of E6AP-E6 complex in Att2 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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4EMM
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3G5X
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3G5Z
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3G5V
| Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR | 分子名称: | 806 light chain, 808 heavy chain, ACETATE ION, ... | 著者 | Garrett, T.P.J, Burgess, A.W, Huyton, T, Xu, Y. | 登録日 | 2009-02-05 | 公開日 | 2010-02-09 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Antibodies specifically targeting a locally misfolded region of tumor associated EGFR Proc.Natl.Acad.Sci.USA, 106, 2009
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3G5Y
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7VD4
| Crystal structure of BPTF-BRD with ligand TP248 bound | 分子名称: | 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | 著者 | Lu, T, Lu, H.B. | 登録日 | 2021-09-06 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85659146 Å) | 主引用文献 | Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123, 2022
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7YJ3
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-07-19 | 公開日 | 2023-07-19 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
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