7EU8

Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate

Summary for 7EU8

• Entry DOI: 10.2210/pdb7eu8/pdb
• EMDB information: 31309
• Descriptor: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: nmda receptor, ketamine, enantiomer, rapid antidepressant, cryo-em structure, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 385409.35

Authors

Zhang, T.,Zhang, Y.,Zhu, S. (deposition date: 2021-05-16, release date: 2021-07-28, Last modification date: 2022-10-26)

• Primary citation: Zhang, Y.,Ye, F.,Zhang, T.,Lv, S.,Zhou, L.,Du, D.,Lin, H.,Guo, F.,Luo, C.,Zhu, S.; Structural basis of ketamine action on human NMDA receptors.; Nature, 596:301-305, 2021; PubMed: 34321660; DOI: 10.1038/s41586-021-03769-9

Experimental method

ELECTRON MICROSCOPY (4.07 Å)