7EU8

Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Glutamate receptor ionotropic, NMDA 1	polymer	847	95236.1	2	UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 2B	polymer	862	96575.5	2	UniProt (Q13224) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)
3	E, F, G, I, J... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
4	H (B)	(2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one	non-polymer		237.7	1	Chemie (JC9)

Sequence modifications

B, D: 1 - 842 (UniProt: Q13224)

PDB	External Database	Details
Leu 843	-	expression tag
Glu 844	-	expression tag
Val 845	-	expression tag
Leu 846	-	expression tag
Phe 847	-	expression tag
Gln 848	-	expression tag
Gly 849	-	expression tag
Pro 850	-	expression tag
Ala 851	-	expression tag
Ala 852	-	expression tag
Ala 853	-	expression tag
Ala 854	-	expression tag
Trp 855	-	expression tag
Ser 856	-	expression tag
His 857	-	expression tag
Pro 858	-	expression tag
Gln 859	-	expression tag
Phe 860	-	expression tag
Glu 861	-	expression tag
Lys 862	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	383623.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1786.2
All*	Total formula weight	385409.4

*Water molecules are not included.