7EU8
Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1400 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | ARG27-ASP557 | |
| B | THR647-ASN817 | |
| D | ARG27-ASP557 | |
| D | THR647-ASN817 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | VAL558-VAL576 | |
| B | MET631-TYR646 | |
| B | MET818-ILE837 | |
| D | VAL558-VAL576 | |
| D | MET631-TYR646 | |
| D | MET818-ILE837 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | PHE577-GLY603 | |
| B | LYS624-ILE630 | |
| D | PHE577-GLY603 | |
| D | LYS624-ILE630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | LYS604-PRO623 | |
| D | LYS604-PRO623 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | HIS127 | |
| D | ARG519 | |
| D | SER690 | |
| D | ASP732 | |
| B | GLU284 | |
| B | THR514 | |
| B | ARG519 | |
| B | SER690 | |
| B | ASP732 | |
| D | HIS127 | |
| D | GLU284 | |
| D | THR514 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN615 | |
| A | ASN491 | |
| A | ASN674 | |
| A | ASN771 | |
| C | ASN61 | |
| C | ASN203 | |
| C | ASN239 | |
| C | ASN276 | |
| C | ASN300 | |
| C | ASN350 | |
| C | ASN368 | |
| D | ASN615 | |
| C | ASN440 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN674 | |
| C | ASN771 | |
| A | ASN239 | |
| A | ASN276 | |
| A | ASN300 | |
| A | ASN350 | |
| A | ASN368 | |
| A | ASN440 | |
| A | ASN471 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN74 | |
| D | ASN348 | |
| D | ASN444 | |
| D | ASN491 | |
| D | ASN542 | |
| D | ASN688 | |
| B | ASN341 | |
| B | ASN348 | |
| B | ASN444 | |
| B | ASN491 | |
| B | ASN542 | |
| B | ASN688 | |
| D | ASN74 | |
| D | ASN341 |
