7EU7

Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate

Summary for 7EU7

• Entry DOI: 10.2210/pdb7eu7/pdb
• EMDB information: 31308
• Descriptor: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: nmda receptor, ketamine, enantiomer, rapid antidepressant, cryo-em structure, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 384735.30

Authors

Zhang, Y.,Zhang, T.,Zhu, S. (deposition date: 2021-05-16, release date: 2021-08-04, Last modification date: 2022-10-26)

• Primary citation: Zhang, Y.,Ye, F.,Zhang, T.,Lv, S.,Zhou, L.,Du, D.,Lin, H.,Guo, F.,Luo, C.,Zhu, S.; Structural basis of ketamine action on human NMDA receptors.; Nature, 596:301-305, 2021; PubMed: 34321660; DOI: 10.1038/s41586-021-03769-9

Experimental method

ELECTRON MICROSCOPY (3.5 Å)