7V1M
 
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8Z0R
 | | Cryo-EM structure of tetramer HtmB2-CT | | 分子名称: | special condensation domain in NRPS | | 著者 | Sun, Y.H, Zhang, Z.Y, Mei, Q. | | 登録日 | 2024-04-10 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Formation of the Diketopiperazine Moiety by a Distinct Condensation-Like Domain in Hangtaimycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8Z0Q
 | | Cryo-EM structure of dimer HtmB2-CT | | 分子名称: | Special condensation domain in NRPS | | 著者 | Sun, Y.H, Zhang, Z.Y, Mei, Q. | | 登録日 | 2024-04-10 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Formation of the Diketopiperazine Moiety by a Distinct Condensation-Like Domain in Hangtaimycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8Z0S
 | | Cryo-EM structure of trimer HtmB2-CT | | 分子名称: | special condensation domain in NRPS | | 著者 | Sun, Y.H, Zhang, Z.Y, Mei, Q. | | 登録日 | 2024-04-10 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Formation of the Diketopiperazine Moiety by a Distinct Condensation-Like Domain in Hangtaimycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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3M3W
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5V2N
 | | Crystal Structure of APO Human SETD8 | | 分子名称: | 1,2-ETHANEDIOL, N-lysine methyltransferase KMT5A | | 著者 | Skene, R.J. | | 登録日 | 2017-03-05 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The dynamic conformational landscape of the protein methyltransferase SETD8.
Elife, 8, 2019
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4OR6
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7XH8
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7BW6
 | | Varicella-zoster virus capsid | | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | | 著者 | Wang, P.Y, Qi, J.X, Liu, C.C, Sun, J.Q. | | 登録日 | 2020-04-13 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the varicella-zoster virus A-capsid.
Nat Commun, 11, 2020
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7DHT
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3QE6
 | | Mouse PACSIN 3 F-BAR domain structure | | 分子名称: | MAGNESIUM ION, Protein kinase C and casein kinase II substrate protein 3 | | 著者 | Meng, G, Bai, X, Zheng, X. | | 登録日 | 2011-01-19 | | 公開日 | 2012-01-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules
J.Biol.Chem., 287, 2012
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2O3C
 | | Crystal structure of zebrafish Ape | | 分子名称: | APEX nuclease 1, LEAD (II) ION | | 著者 | Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J. | | 登録日 | 2006-12-01 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
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1VRH
 | | HRV14/SDZ 880-061 COMPLEX | | 分子名称: | 2-[4-(2H-1,4-BENZOTHIAZINE-3-YL)-PIPERAZINE-1-LY]-1,3-THIAZOLE-4-CARBOXYLIC ACID ETHYLESTER, RHINOVIRUS 14 | | 著者 | Oren, D.A, Zhang, A, Arnold, E. | | 登録日 | 1996-02-26 | | 公開日 | 1997-02-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14.
J.Mol.Biol., 259, 1996
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8K4B
 | | Cryo-EM structure of nucleotide-bound ComA with ZinC ion | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Competence factor transporting ATP-binding protein/permease ComA, ZINC ION | | 著者 | Yu, L, Xin, X, Min, L, Feng, H. | | 登録日 | 2023-07-17 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
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8K7A
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3BXW
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3CTF
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5UR2
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4H12
 | | The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-09-10 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
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4HC4
 | | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Protein arginine N-methyltransferase 6, ... | | 著者 | Dong, A, Zeng, H, He, H, El Bakkouri, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-09-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
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5T5G
 | | human SETD8 in complex with MS2177 | | 分子名称: | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | | 著者 | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2016-08-30 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
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5TH7
 | | Complex of SETD8 with MS453 | | 分子名称: | 1,2-ETHANEDIOL, N-(3-{[6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)propanamide, N-lysine methyltransferase KMT5A, ... | | 著者 | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2016-09-29 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
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2O3H
 | | Crystal structure of the human C65A Ape | | 分子名称: | ACETATE ION, DNA-(apurinic or apyrimidinic site) lyase, SAMARIUM (III) ION | | 著者 | Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J. | | 登録日 | 2006-12-01 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
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8K14
 | | X-ray crystal structure of 18a in BRD4(1) | | 分子名称: | 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4 | | 著者 | Xu, H, Shen, H, Zhang, Y, Xu, Y, Li, R. | | 登録日 | 2023-07-10 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation.
Eur.J.Med.Chem., 263, 2024
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4I51
 | | Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A | | 分子名称: | GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ... | | 著者 | Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-11-28 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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