5TH7

Complex of SETD8 with MS453

Summary for 5TH7

Entry DOI	10.2210/pdb5th7/pdb
Descriptor	N-lysine methyltransferase KMT5A, N-(3-{[6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)propanamide, UNKNOWN ATOM OR ION, ... (5 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q9NQR1
Total number of polymer chains	2
Total formula weight	34398.76
Authors	Yu, W.,Tempel, W.,Babault, N.,Ma, A.,Butler, K.V.,Jin, J.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-29, release date: 2016-11-09, Last modification date: 2024-04-03)
Primary citation	Butler, K.V.,Ma, A.,Yu, W.,Li, F.,Tempel, W.,Babault, N.,Pittella-Silva, F.,Shao, J.,Wang, J.,Luo, M.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Jin, J. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J. Med. Chem., 59:9881-9889, 2016 Cited by PubMed: 27804297 DOI: 10.1021/acs.jmedchem.6b01244 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation