5TH7
Complex of SETD8 with MS453
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase KMT5A | polymer | 148 | 16780.9 | 2 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
| 2 | C, P (A, B) | N-(3-{[6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)propanamide | non-polymer | 387.5 | 2 | Chemie (7BY) | |||
| 3 | D, E, F, G, H... (A, B) | UNKNOWN ATOM OR ION | non-polymer | 21 | Chemie (UNX) | ||||
| 4 | O (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | AA, BA (A, B) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B: 234 - 380 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 233 | - | expression tag |
| Ser 343 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33561.7 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 837.0 | |
| All* | Total formula weight | 34398.8 |
