6PM2
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, open state | 分子名称: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM0
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, super-open state | 分子名称: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM3
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, closed state | 分子名称: | 2-AMINOETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM5
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, desensitized state | 分子名称: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM6
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, open state | 分子名称: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLW
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, super-open state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLP
| CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA, desensitized state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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5D41
| EGFR kinase domain in complex with mutant selective allosteric inhibitor | 分子名称: | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Yun, C.-H, Park, E, Eck, M.J. | 登録日 | 2015-08-07 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534, 2016
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8HZ8
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3KKI
| PLP-Dependent Acyl-CoA transferase CqsA | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CAI-1 autoinducer synthase, MAGNESIUM ION, ... | 著者 | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | 登録日 | 2009-11-05 | 公開日 | 2009-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
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1RJI
| Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch | 分子名称: | potassium channel toxin KX | 著者 | Cai, Z, Wu, J, Xu, Y, Wang, C.-G, Chi, C.-W, Shi, Y. | 登録日 | 2003-11-19 | 公開日 | 2003-12-09 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi karsch, sequencing, gene cloning and structure determination Toxicon, 45, 2005
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3HQT
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6TFM
| Frizzled8 CRD | 分子名称: | Frizzled-8 | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-14 | 公開日 | 2020-03-04 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6TFB
| Carbamazepine binds Frizzled8 | 分子名称: | Frizzled-8, GLYCEROL, benzo[b][1]benzazepine-11-carboxamide | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-13 | 公開日 | 2020-02-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6TR7
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6TR6
| N-acetylserotonin-Notum complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-12-17 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68, 2020
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6U4J
| Crystal structure of IDH1 R132H mutant in complex with FT-2102 | 分子名称: | 5-{[(1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile, CHLORIDE ION, CITRATE ANION, ... | 著者 | Toms, A.V, Lin, J. | 登録日 | 2019-08-25 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor. J.Med.Chem., 63, 2020
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6TV4
| CFF-Notum complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CAFFEINE, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-01-08 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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6TUZ
| Theophylline-Notum complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-01-08 | 公開日 | 2020-10-28 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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4E86
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6TR5
| Melatonin-Notum complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-12-17 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.509 Å) | 主引用文献 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68, 2020
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4E82
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4E83
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2P5X
| Crystal structure of Maf domain of human N-acetylserotonin O-methyltransferase-like protein | 分子名称: | N-acetylserotonin O-methyltransferase-like protein, PHOSPHATE ION | 著者 | Min, J, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-03-16 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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4LU1
| Crystal structure of the uncharacterized Maf protein YceF from E. coli, mutant D69A | 分子名称: | Maf-like protein YceF, UNKNOWN ATOM OR ION | 著者 | Dong, A, Xu, X, Cui, H, Tchigvintsev, A, Flick, R, Brown, G, Popovic, A, Yakunin, A.F, Savchenko, A, Structural Genomics Consortium (SGC) | 登録日 | 2013-07-24 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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