4E82

Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)

Summary for 4E82

Entry DOI	10.2210/pdb4e82/pdb
Related	1ZMP 4E83 4E86
Descriptor	Defensin-5 (2 entities in total)
Functional Keywords	monomeric variant, antimicrobial peptide, glu21 methylation, paneth cells, antimicrobial protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q01523
Total number of polymer chains	2
Total formula weight	7216.51
Authors	Pazgier, M. (deposition date: 2012-03-19, release date: 2012-05-16, Last modification date: 2023-11-15)
Primary citation	Rajabi, M.,Ericksen, B.,Wu, X.,de Leeuw, E.,Zhao, L.,Pazgier, M.,Lu, W. Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface. J.Biol.Chem., 287:21615-21627, 2012 Cited by PubMed: 22573326 DOI: 10.1074/jbc.M112.367995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation