6TR5

Melatonin-Notum complex

Summary for 6TR5

Entry DOI	10.2210/pdb6tr5/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	wnt notum inhibitor melatonin, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45099.55
Authors	Zhao, Y.,Jones, E.Y. (deposition date: 2019-12-17, release date: 2020-01-15, Last modification date: 2024-01-24)
Primary citation	Zhao, Y.,Ren, J.,Hillier, J.,Jones, M.,Lu, W.,Jones, E.Y. Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68:e12630-e12630, 2020 Cited by PubMed: 31876313 DOI: 10.1111/jpi.12630 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.509 Å)

Structure validation