9BER
 
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9BF6
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7Y7M
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6W51
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8E7B
 | | Crystal structure of the p53 (Y107H) core domain monoclinic P form | | 分子名称: | Cellular tumor antigen p53, ZINC ION | | 著者 | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | | 登録日 | 2022-08-23 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
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8E7A
 | | Crystal structure of the p53 (Y107H) core domain orthorhombic P form | | 分子名称: | Cellular tumor antigen p53, ZINC ION | | 著者 | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | | 登録日 | 2022-08-23 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
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6OE8
 | | The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C | | 分子名称: | MALONATE ION, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | | 著者 | Shi, Y, Wang, T, Zhou, X.E, Liu, Q, Jiang, Y, Xu, H.E. | | 登録日 | 2019-03-27 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy.
Acta Pharmacol.Sin., 40, 2019
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4U97
 | | Crystal Structure of Asymmetric IRAK4 Dimer | | 分子名称: | Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION | | 著者 | Ferrao, R, Wu, H. | | 登録日 | 2014-08-05 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
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1EQ0
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1EQM
 | | CRYSTAL STRUCTURE OF BINARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE WITH ADENOSINE-5'-DIPHOSPHATE | | 分子名称: | 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Xiao, B, Blaszczyk, J, Ji, X. | | 登録日 | 2000-04-05 | | 公開日 | 2001-04-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMR.
J.Biol.Chem., 276, 2001
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4XT9
 | | RORgamma (263-509) complexed with GSK2435341A and SRC2 | | 分子名称: | LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... | | 著者 | Wang, Y, Ma, Y. | | 登録日 | 2015-01-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
Bioorg.Med.Chem., 23, 2015
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4MMG
 | | crystal structure of YafQ mutant H87Q from E.coli | | 分子名称: | SULFATE ION, mRNA interferase YafQ | | 著者 | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | | 登録日 | 2013-09-09 | | 公開日 | 2014-06-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ
J.Biol.Chem., 289, 2014
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4ML0
 | | Crystal structure of E.coli DinJ-YafQ complex | | 分子名称: | Predicted antitoxin of YafQ-DinJ toxin-antitoxin system, Predicted toxin of the YafQ-DinJ toxin-antitoxin system, SULFATE ION | | 著者 | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | | 登録日 | 2013-09-06 | | 公開日 | 2014-06-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ
J.Biol.Chem., 289, 2014
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4ML2
 | | Crystal structure of wild-type YafQ | | 分子名称: | SULFATE ION, mRNA interferase YafQ | | 著者 | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | | 登録日 | 2013-09-06 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ
J.Biol.Chem., 289, 2014
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4GG5
 | | Crystal structure of CMET in complex with novel inhibitor | | 分子名称: | 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine, Hepatocyte growth factor receptor | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-08-05 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.423 Å) | | 主引用文献 | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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5GTY
 | | Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, Epidermal growth factor receptor | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2016-08-23 | | 公開日 | 2017-09-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode.
Oncotarget, 8, 2017
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3IPY
 | | X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor | | 分子名称: | 4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine, D-MALATE, Deoxycytidine kinase | | 著者 | Tari, L.W, Swanson, R.V, Hunter, M, Hoffman, I, Stouch, T.R, Carson, K.G. | | 登録日 | 2009-08-18 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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3IPX
 | | X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor | | 分子名称: | 2'-deoxy-5-fluorocytidine, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, ... | | 著者 | Tari, L.W, Swanson, R.V, Hunter, M, Hoffman, I, Stouch, T.R, Carson, K.G. | | 登録日 | 2009-08-18 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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5IFG
 | | Crystal structure of HigA-HigB complex from E. Coli | | 分子名称: | Antitoxin HigA, mRNA interferase HigB | | 著者 | Yang, J.S, Zhou, K, Gao, z.Q, Liu, Q.S, Dong, Y.H. | | 登録日 | 2016-02-26 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | | 主引用文献 | Structural insight into the E. coli HigBA complex
Biochem. Biophys. Res. Commun., 478, 2016
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4GG7
 | | Crystal structure of cMET in complex with novel inhibitor | | 分子名称: | Hepatocyte growth factor receptor, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-08-06 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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7YNX
 | | Crystal structure of Pirh2 bound to poly-Ala peptide | | 分子名称: | RING finger and CHY zinc finger domain-containing protein 1, SODIUM ION, SULFATE ION, ... | | 著者 | Dong, C, Yan, X, Li, Y. | | 登録日 | 2022-08-01 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Recognition of an Ala-rich C-degron by the E3 ligase Pirh2.
Nat Commun, 14, 2023
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2GH2
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8X7V
 | | Structure of human SCMC ternary complex | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | | 著者 | Chi, P, Ou, G, Liu, S, Lu, Y, Li, J.H, Li, J.L, Wang, X, Deng, D. | | 登録日 | 2023-11-26 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants.
Nat.Struct.Mol.Biol., 2024
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8X7W
 | | Structure of dimeric human SCMC complex | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | | 著者 | Chi, P, Ou, G, Liu, S, Lu, Y, Li, J, Li, J, Wang, X, Deng, D. | | 登録日 | 2023-11-26 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants.
Nat.Struct.Mol.Biol., 2024
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7L97
 | | Crystal structure of STAMBPL1 in complex with an engineered binder | | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease, SULFATE ION, ... | | 著者 | Guo, Y, Dong, A, Hou, F, Li, Y, Zhang, W, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2021-01-02 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
J.Biol.Chem., 297, 2021
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