4GG7

Crystal structure of cMET in complex with novel inhibitor

Summary for 4GG7

• Entry DOI: 10.2210/pdb4gg7/pdb
• Related: 4GG5
• Descriptor: Hepatocyte growth factor receptor, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: c-met inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 36532.05

Authors

Liu, Q.F.,Chen, T.T.,Xu, Y.C. (deposition date: 2012-08-06, release date: 2012-10-03, Last modification date: 2024-02-28)

• Primary citation: Wu, K.,Ai, J.,Liu, Q.,Chen, T.,Zhao, A.,Peng, X.,Wang, Y.,Ji, Y.,Yao, Q.,Xu, Y.,Geng, M.,Zhang, A.; Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.; Bioorg.Med.Chem.Lett., 22:6368-6372, 2012; PubMed: 22985853; DOI: 10.1016/j.bmcl.2012.08.075

Experimental method

X-RAY DIFFRACTION (2.27 Å)