4GG7
Crystal structure of cMET in complex with novel inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 319 | 36033.6 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
2 | A | N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | non-polymer | 498.5 | 1 | Chemie (0J8) | |||
3 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1028 | - | expression tag |
Gly 1029 | - | expression tag |
Ser 1030 | - | expression tag |
Ser 1031 | - | expression tag |
His 1032 | - | expression tag |
His 1033 | - | expression tag |
His 1034 | - | expression tag |
His 1035 | - | expression tag |
His 1036 | - | expression tag |
His 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36033.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 498.5 | |
All* | Total formula weight | 36532.1 |