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4GG5

Crystal structure of CMET in complex with novel inhibitor

Summary for 4GG5
Entry DOI10.2210/pdb4gg5/pdb
Related4GG7
DescriptorHepatocyte growth factor receptor, 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine (3 entities in total)
Functional Keywordscmet inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains1
Total formula weight36479.03
Authors
Liu, Q.F.,Chen, T.T.,Xu, Y.C. (deposition date: 2012-08-05, release date: 2012-10-03, Last modification date: 2024-02-28)
Primary citationWu, K.,Ai, J.,Liu, Q.,Chen, T.,Zhao, A.,Peng, X.,Wang, Y.,Ji, Y.,Yao, Q.,Xu, Y.,Geng, M.,Zhang, A.
Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22:6368-6372, 2012
Cited by
PubMed: 22985853
DOI: 10.1016/j.bmcl.2012.08.075
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.423 Å)
Structure validation

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