4GG5
Crystal structure of CMET in complex with novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 319 | 36033.6 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | B (A) | 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine | non-polymer | 445.4 | 1 | Chemie (0J3) | |||
| 3 | C (A) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1028 | - | expression tag |
| Gly 1029 | - | expression tag |
| Ser 1030 | - | expression tag |
| Ser 1031 | - | expression tag |
| His 1032 | - | expression tag |
| His 1033 | - | expression tag |
| His 1034 | - | expression tag |
| His 1035 | - | expression tag |
| His 1036 | - | expression tag |
| His 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36033.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 445.4 | |
| All* | Total formula weight | 36479.0 |
