4GG7
Crystal structure of cMET in complex with novel inhibitor
Summary for 4GG7
Entry DOI | 10.2210/pdb4gg7/pdb |
Related | 4GG5 |
Descriptor | Hepatocyte growth factor receptor, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | c-met inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 36532.05 |
Authors | Liu, Q.F.,Chen, T.T.,Xu, Y.C. (deposition date: 2012-08-06, release date: 2012-10-03, Last modification date: 2024-02-28) |
Primary citation | Wu, K.,Ai, J.,Liu, Q.,Chen, T.,Zhao, A.,Peng, X.,Wang, Y.,Ji, Y.,Yao, Q.,Xu, Y.,Geng, M.,Zhang, A. Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg.Med.Chem.Lett., 22:6368-6372, 2012 Cited by PubMed: 22985853DOI: 10.1016/j.bmcl.2012.08.075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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