6A6J
| Crystal structure of Zebra fish Y-box protein1 (YB-1) Cold-shock domain in complex with 6mer m5C RNA | 分子名称: | RNA (5'-R(P*CP*AP*UP*(5MC)P*U)-3'), ZINC ION, Zebra fish Y-box protein1 (YB-1) | 著者 | Zhang, M.M, Wu, B.X, Huang, Y, Ma, J.B. | 登録日 | 2018-06-28 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.255 Å) | 主引用文献 | RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol.Cell, 75, 2019
|
|
4ZZH
| SIRT1/Activator Complex | 分子名称: | (4S)-N-[3-(1,3-oxazol-5-yl)phenyl]-7-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-methanopyrido[2,3-b][1,4]diazepine-5(2H)-carboxamide, NAD-dependent protein deacetylase sirtuin-1, ZINC ION | 著者 | Dai, H. | 登録日 | 2015-05-22 | 公開日 | 2015-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1001 Å) | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun, 6, 2015
|
|
4ZZI
| SIRT1/Activator/Inhibitor Complex | 分子名称: | (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, NAD-dependent protein deacetylase sirtuin-1, ... | 著者 | Dai, H. | 登録日 | 2015-05-22 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7346 Å) | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun, 6, 2015
|
|
8DY2
| Crystal Structure of spFv GLK1 | 分子名称: | SULFATE ION, spFv GLK1 LH | 著者 | Luo, J, Boucher, L.E. | 登録日 | 2022-08-03 | 公開日 | 2023-05-03 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15, 2023
|
|
8DY4
| |
8DY5
| |
8DY0
| |
8DY3
| |
8DY1
| |
6MT0
| Crystal structure of human Pim-1 kinase in complex with a quinazolinone-pyrrolodihydropyrrolone inhibitor | 分子名称: | 3-(1-methylcyclopropyl)-2-[(1-methylcyclopropyl)amino]-8-[(6R)-6-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl]quinazolin-4(3H)-one, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Mohr, C. | 登録日 | 2018-10-18 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies. J. Med. Chem., 62, 2019
|
|
6IYF
| Structure of pSTING complex | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, SULFATE ION, Stimulator of interferon genes protein | 著者 | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | 登録日 | 2018-12-15 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.764 Å) | 主引用文献 | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem., 294, 2019
|
|
4KDC
| Crystal Structure of UBIG | 分子名称: | 3-demethylubiquinone-9 3-methyltransferase | 著者 | Zhu, Y, Teng, M, Li, X. | 登録日 | 2013-04-24 | 公開日 | 2014-04-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins. Biochem. J., 470, 2015
|
|
7T86
| Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab CR5133 Heavy Chain, Antibody Fab CR5133 Light Chain, ... | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | 登録日 | 2021-12-15 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Cell Host Microbe, 31, 2023
|
|
7T82
| Crystal Structure of LEUKOCIDIN E/CENTYRIN S26/FAB B438 | 分子名称: | Antibody Fab Heavy Chain, Antibody Fab Light Chain, Centyrin S26, ... | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | 登録日 | 2021-12-15 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Cell Host Microbe, 31, 2023
|
|
7T87
| CRYSTAL STRUCTURE OF LEUKOCIDIN AB/CENTYRIN S17/FAB 214F COMPLEX | 分子名称: | Antibody Fab B214 Heavy Chain, Antibody Fab B214 Light Chain, Centyrin S17, ... | 著者 | Luo, J, Malia, T.J, Buckley, P.T. | 登録日 | 2021-12-15 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Cell Host Microbe, 31, 2023
|
|
5EOL
| |
8WGW
| Local refinement of RBD-ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Wei, X, Zhang, Z. | 登録日 | 2023-09-22 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
|
|
8WGV
| BA.2(S375) Spike (S6P)/hACE2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Wei, X, Zhang, Z. | 登録日 | 2023-09-22 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
|
|
6KBU
| Crystal structure of yedK | 分子名称: | GLYCEROL, SOS response-associated protein | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-06-26 | 公開日 | 2019-07-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
|
|
6KIJ
| Crystal structure of yedK with ssDNA containing an abasic site | 分子名称: | DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ... | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-07-18 | 公開日 | 2019-08-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
|
|
6KBZ
| |
8DYF
| IL17A homodimer bound to Compound 10 | 分子名称: | (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A | 著者 | Argiriadi, M.A, Goedken, E.R. | 登録日 | 2022-08-04 | 公開日 | 2022-09-07 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
|
|
8DYG
| IL17A homodimer bound to Compound 7 | 分子名称: | (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A | 著者 | Argiriadi, M.A, Goedken, E.R. | 登録日 | 2022-08-04 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
|
|
8DYH
| IL17A homodimer bound to Compound 6 | 分子名称: | (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A | 著者 | Argiriadi, M.A, Goedken, E.R. | 登録日 | 2022-08-04 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
|
|
8DYI
| IL17A homodimer bound to Compound 5 | 分子名称: | (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A | 著者 | Argiriadi, M.A, Goedken, E.R. | 登録日 | 2022-08-04 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
|
|